Collision of desmoplastic-neurotropic melanoma and squamous cell carcinoma on the lip

Journal of Cutaneous Pathology
Vincent FalangaLance Tibbetts

Abstract

We report on a case of the collision of a desmoplastic-neurotropic melanoma and a squamous cell carcinoma on the lip. A 46-year-old male developed a multifocal infiltrative squamous cell carcinoma of the lower lip, which also showed sparse melanocyte atypia within the epidermis and an extensive spindle cell proliferation within the dermis, subcutaneous tissues and nerves. An immunohistochemical panel showed that the spindle cells were melanocytes, not derived from the squamous cell carcinoma. Double labeling with AE1/AE3 and S100 showed striking localized proximity of the spindle-cell melanocytic and keratinocyte components in some areas of this tumor. To our knowledge, this is the first report of the collision of a squamous cell carcinoma and desmoplastic-neurotropic melanoma.

References

Jun 1, 1977·Southern Medical Journal·A W BoddieR M Byers
Jul 1, 1988·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J B KippaxW Gilmore
Dec 1, 1995·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·H NakaharaK Shirasuna
Jan 1, 1997·Dermatology : International Journal for Clinical and Investigative Dermatology·M AkiyamaK Nakamura
Jun 1, 1997·The American Journal of Dermatopathology·A Burkhalter, W L White
Jan 1, 1997·Dermatology : International Journal for Clinical and Investigative Dermatology·G E PiérardC Piérard-Franchimont
Sep 11, 2001·Dermatology : International Journal for Clinical and Investigative Dermatology·A HoferP Wolf
Apr 1, 2004·Head & Neck·Manju L PrasadKlaus J Busam
Aug 27, 2005·The American Journal of Dermatopathology·Annie BelisleJanine Wechsler
Dec 7, 2005·The American Journal of Surgical Pathology·Klaus J BusamAshfaq A Marghoob
Jun 17, 2006·Journal of Cutaneous Pathology·Jorge E Dotto, Earl J Glusac

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Citations

Jul 11, 2009·The American Journal of Dermatopathology·Mariya MitevaPaolo Romanelli
Aug 13, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jessica M ScruggsDavid F Butler
Jul 26, 2015·Journal of the American Academy of Dermatology·Sapna M AminPedram Gerami
Sep 29, 2012·Dermatology : International Journal for Clinical and Investigative Dermatology·Holger A HaenssleHans P Bertsch
Aug 19, 2010·Allergy·J R CernadasUNKNOWN European Network of Drug Allergy and the EAACI interest group on drug hypersensitivity

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