PMID: 8611639Feb 2, 1996Paper

Collisions and encounters in simulations of receptor/GTP-binding protein interactions via simple diffusion

Biochimica Et Biophysica Acta
D Stickle, R Barber

Abstract

In two intact cell systems in which GTP-binding protein (G) activity is initiated by the presence of agonist-bound receptors (R), it has been demonstrated that the rate of G activation is influenced by the rate of turnover of agonist occupancy among the receptor population. G activity is reduced when a low concentration of agonist-occupied receptors comprised by low fractional occupancy of a large receptor population is replaced by the presence of the same concentration of 100%-occupied receptors. This effect has been proposed to be due to a time interval of interaction between R and G (an encounter) that is long compared to the time of a single collection between R and G and long compared to the lifetime of an agonist-receptor complex. In a recent simulation study of R-G interaction via diffusion, the effect of agonist occupancy turnover was observed but it was assumed that long encounters were not operative. In this study, encounter intervals in simulations of R-G interaction by simple diffusion were measured in order to address that difference. The results demonstrate that relatively long encounters comprised of multiple, separate collisions are an inherent part of R-G interaction as modelled by diffusion. The implications f...Continue Reading

References

Dec 8, 1976·Biochimica Et Biophysica Acta·D Cassel, Z Selinger
Aug 12, 1988·Science·A Levitzki
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C Chavkin, A Goldstein
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S Strickland, J N Loeb

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Citations

May 24, 2000·European Journal of Pharmacology·A E RemmersJ R Traynor
Apr 18, 2006·Progress in Lipid Research·Thomas J Pucadyil, Amitabha Chattopadhyay
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·John R TraynorAnn E Remmers

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