Colloid scintigraphy in non-alcoholic steatohepatitis: a conventional diagnostic method for an emerging disease

Nuclear Medicine Communications
Deniz Güney DumanNurdan Tözün

Abstract

Non-alcoholic steatohepatitis (NASH) is a progressive liver disease characterized by diffuse fatty infiltration and Kupffer cell dysfunction which contributes to its pathogenesis. Since the liver biopsy, which is considered the 'gold standard' in diagnosing NASH, has some limitations other imaging methods have been explored as alternatives. Colloid scintigraphy is a good method reflecting Kupffer cell activity and we found it worthwhile to evaluate this technique in NASH. We aimed to present the common scintigraphic features and their clinicopathologic correlations in NASH. Twenty-two new patients (11 female, mean age 43.7+/-10.8) with biopsy-proven NASH underwent colloid liver scintigraphy. The dynamic, static and SPECT images were performed after intravenous injection of 185 MBq Tc tin colloid. Hepatic perfusion, blood pool clearance time, colloid shift to spleen and bone marrow were assessed and liver right/left lobe ratio was calculated. The values calculated on static and tomographic (SPECT) images showed good correlation. Liver right/left lobe ratio was altered in all patients. Blood pool clearance time was prolonged in seven (32%) but hepatic perfusion was normal in all patients. Colloid shift to the spleen was observed ...Continue Reading

References

Apr 12, 2001·Seminars in Liver Disease·E M Brunt
Dec 26, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anna Mae Diehl
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brent A Neuschwander-Tetri, Stephen H Caldwell
Mar 15, 2006·Digestive Diseases and Sciences·Deniz Güney DumanNurdan Tözün

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Citations

Jul 25, 2009·World Journal of Gastroenterology : WJG·Giovanni Tarantino
Oct 12, 2011·World Journal of Gastroenterology : WJG·Giovanni TarantinoAnnamaria Colao
Jun 27, 2013·World Journal of Gastroenterology : WJG·Giovanni TarantinoCarmine Finelli
Jul 16, 2010·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Wei-Jen ShihPrimo P Milan
May 23, 2013·Clinical Physiology and Functional Imaging·Fatma J Al-Saeedi, Behling Cheng
Jun 9, 2016·Nature Reviews. Gastroenterology & Hepatology·Christopher LeungPeter W Angus

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