Colloid vs. crystalloid infusions in gastrointestinal surgery and their different impact on the healing of intestinal anastomoses.

International Journal of Colorectal Disease
Goran MarjanovicRobert Obermaier

Abstract

The aim of this study was to investigate if colloid infusions have different effects on intestinal anastomotic healing when compared to crystalloid infusions depending on the amount of the administered volume. Twenty-eight Wistar rats were randomly assigned to four groups receiving different amounts of either a crystalloid (Cry) or a colloid (Col) infusion solution. Animals with volume restriction (Cry (-) or Col (-)) were treated with a low and animals with volume overcharge (Cry (+) or Col (+)) with a high flow rate. All animals received an infusion for a 60-min period, while an end-to-end small bowel anastomosis was performed. At reoperation, the anastomotic bursting pressure (millimeters of mercury) was measured, as well as anastomotic hydroxyproline concentration. The presence of bowel wall edema was assessed histologically. Median bursting pressures were comparable in the Col (-) [118 mm Hg (range 113-170)], the Cry (-) [118 mm Hg (78-139)], and the Col (+) [97 mm Hg (65-152)] group. A significantly lower median bursting pressure was found in animals with crystalloid volume overload Cry (+) [73 mm Hg (60-101)]. Corresponding results were found for hydroxyproline concentration. Histology revealed submucosal edema in Cry (+...Continue Reading

Associated Clinical Trials

Oct 25, 2018·Jason Jennings, Jason Jennings

References

Nov 1, 1990·British Journal of Anaesthesia·I T CampbellS J Keens
Jun 1, 1996·Clinical Biochemistry·G K Reddy, C S Enwemeka
Jun 1, 1997·The Surgical Clinics of North America·F J Thornton, A Barbul
Apr 23, 2003·Anesthesia and Analgesia·Kathrine HolteHenrik Kehlet
Dec 6, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Katrin LangDietmar Nagel
Jun 18, 2004·Vox Sanguinis·M Mythen, A Vercueil
Sep 18, 2004·The Proceedings of the Nutrition Society·Dileep N Lobo
Mar 23, 2005·Anesthesia and Analgesia·Michael P W GrocottTong J Gan
Jun 29, 2005·Anesthesiology·Vadim NisanevichIdit Matot
Jun 19, 2007·Lancet·Matthias JacobMarkus Rehm
Feb 13, 2009·Annals of Surgery·Goran MarjanovicRobert Obermaier
Feb 13, 2009·Annals of Surgery·Dileep N Lobo
Mar 24, 2009·Critical Care : the Official Journal of the Critical Care Forum·Luzius B HiltebrandGisli H Sigurdsson

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Citations

Apr 2, 2011·World Journal of Gastroenterology : WJG·Philipp Anton HolznerGoran Marjanovic
Feb 26, 2011·Der Anaesthesist·B NohéK Unertl
Apr 13, 2013·The Journal of Surgical Research·Carolyn NessimPierre Dubé
Sep 24, 2015·Journal of Veterinary Emergency and Critical Care·Alexandra G RafteryPaul D MacFarlane
Oct 24, 2012·Anesthesiology Clinics·J Michael JaegerRandal S Blank
Nov 26, 2010·Current Opinion in Anaesthesiology·Ju-Mei Ng
Jun 18, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Abeed H Chowdhury, Dileep N Lobo
Feb 16, 2011·Current Opinion in Anaesthesiology

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