Colloidal carriers for extended absorption window of furosemide

The Journal of Pharmacy and Pharmacology
Amal A SultanGamal M El Maghraby

Abstract

The aim was to investigate the potential of self-microemulsifying drug delivery systems (SMEDDS) and niosomes as carriers for widening the gastrointestinal absorption window of furosemide (model acidic drug). The drug was incorporated in SMEDDS and was encapsulated into niosomes. The intestinal absorption was monitored at two anatomical sites (duodenum and jejuno-ileum). This employed in situ rabbit intestinal perfusion technique. Perfusion of drug solution (control) revealed poor intestinal permeability with per cent fraction absorbed (%Fa) from the duodenum and jejuno-ileum being 1.3 and 0.6 % per cm, respectively. Formulation of furosemide as SMEDDS increased the %Fa from the duodenum and jejuno-ileum to reach 1.7 and 1 % per cm, respectively. Niosomal encapsulation increased the %Fa from duodenum and jejuno-ileum to record 1.9 and 1.2 % per cm, respectively. The increase in the %Fa was also revealed as a reduction in the length required for 95 % absorption of the drug which was reduced from 557.2 to 245.8 cm and to 279.8 cm after delivery as niosomes or SMEDDS, respectively, in case of jejuno-ileum. The same trend was recorded with the duodenum. The recorded results highlighted the potential for SMEDDS and niosomes for wide...Continue Reading

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Citations

Oct 22, 2016·Colloids and Surfaces. B, Biointerfaces·Amal A SultanGamal M El Maghraby
Jun 18, 2017·Journal of Liposome Research·Amal A SultanGamal M El Maghraby
Oct 27, 2018·The Journal of Pharmacy and Pharmacology·Shimaa M AshmawyMohamed A Osman
Aug 17, 2019·Drug Development and Industrial Pharmacy·Heba I ElagamyGamal M El Maghraby
Jul 25, 2018·Minerva chirurgica·Matteo ManfrediFrancesco Porpiglia
Mar 30, 2018·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Antonio GalfanoAldo M Bocciardi
Sep 1, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Antonio TienzaJuan I Pascual
Nov 14, 2018·Parasitology Research·Hager S ZoghrobanMona A Abd Elazeem

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