Colloidal dispersion stability of unilamellar DPPC vesicles in aqueous electrolyte solutions and comparisons to predictions of the DLVO theory

Journal of Colloid and Interface Science
Yoonjee ParkElias I Franses

Abstract

The colloidal dispersion stability at 25 degrees C of aqueous dispersions of sonicated DPPC (dipalmitoylphosphatidylcholine) vesicles was quantitatively evaluated from the Fuchs-Smoluchowski stability ratio W. Data of average particle size vs. time were obtained with dynamic light scattering measurements. Dispersions in water, 1, 10, or 150mM aqueous sodium chloride, and phosphate buffer saline (PBS) solutions were tested. The W-values ranged from about 8x10(6) to 6x10(8). The dispersed particles had small but significant zeta-potentials zeta, implying that the vesicles had some significant charge due to preferential adsorption of negative hydroxyl ions over hydronium ions in water, and chloride ions over sodium ions in the electrolyte solutions. Hence, there was some contribution of the double-layer electrostatic forces to the dispersion stability. The initial values of zeta ranged from -30 to 8mV. The vesicle non-retarded Hamaker constants were estimated from the published values of the Hamaker constants of DPPC and water in vacuum, and they varied with the vesicle size. A new dimensionless model of the DLVO theory for spherical particles was formulated, focusing on the conditions for the existence of a positive interaction p...Continue Reading

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Citations

Feb 18, 2014·Carbohydrate Polymers·Delia MandracchiaRossella Dorati
Jul 12, 2011·Journal of Colloid and Interface Science·Jiannan DongEric Hanson
Nov 2, 2011·Journal of Colloid and Interface Science·Paula ToimilFélix Sarmiento
Mar 14, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Yoonjee ParkJoyce Y Wong
Nov 5, 2013·ACS Nano·Guillermo Iván Guerrero-GarcíaMonica Olvera de la Cruz
Mar 22, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Aniruddha V KelkarDavid S Corti
Nov 5, 2016·Colloids and Surfaces. B, Biointerfaces·M A PalominosM A Soto-Arriaza
Feb 4, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Yoonjee Park, Elias I Franses
Jun 26, 2012·Journal of Colloid and Interface Science·Diógenes de Sousa Neto, Marcel Tabak

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