Colloidal Polymeric Platform for Facile Click-Assisted Ligand Functionalization and Receptor Targeting

ACS Omega
Ruhani SinghNicole M Smith

Abstract

Colloidal poly(glycidyl methacrylate) nanoparticles (NPs) are demonstrated to be platforms facilitating the "click" chemistry approach of surface functionalization for receptor targeting. Folate receptor-targeted NPs were synthesized, physicochemically characterized, confirmed for their biocompatibility, and validated for their selective targeting capabilities for ovarian cancer cells in vitro.

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Citations

Feb 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qi Y WangYue Wang

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Methods Mentioned

BETA
fluorescence imaging
nuclear magnetic resonance
transmission electron microscopy
NMR
flow cytometry
fluorescence-activated cell sorting
FACS

Software Mentioned

GraphPad

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