Colloidal stability of magnetite/poly(lactic acid) core/shell nanoparticles

Langmuir : the ACS Journal of Surfaces and Colloids
S A Gómez-LoperaA V Delgado

Abstract

In this work, we describe an experimental investigation on the colloidal stability of suspensions of three kinds of particles, including magnetite, poly(lactic acid) (PLA), and composite core/shell colloids formed by a magnetite core surrounded by a PLA shell. The experiments were performed with dilute suspensions, so that recording the optical absorbance with time gives a suitable indication of the aggregation and sedimentation of the suspensions. The method allowed us to distinguish very accurately between the different surface and magnetic forces responsible for the structures acquired by particle aggregates. Thus, the pure PLA suspensions are very sensitive to ionic strength and almost unaffected by pH changes. On the contrary, the stability of magnetite systems is mainly controlled by pH. The effect of vertical magnetic fields on the stability of magnetite and magnetite/PLA suspensions is also investigated. The PLA shell reduces the magnetic responsiveness of magnetite, but it is demonstrated that the mixed particles can also form structures induced by the field, despite their lower magnetization, and they can be considered in magnetically targeted biomedical applications.

References

Feb 13, 2001·The Journal of Surgical Research·A S LübbeC Bergemann
Jul 12, 2001·Journal of Colloid and Interface Science·S. A. Gómez-LoperaA. V. Delgado
Dec 6, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·J L AriasA V Delgado
Nov 18, 2005·Journal of Colloid and Interface Science·R C PlazaA V Delgado
Nov 18, 2005·Journal of Colloid and Interface Science·R C PlazaA V Delgado

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Citations

Jul 19, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Joshua E Rosen, Frank X Gu
Mar 24, 2011·Future Medicinal Chemistry·Sophie LaurentRobert N Muller
Jan 1, 2008·Nanoscale Research Letters·Wei WuChangzhong Jiang
Feb 25, 2009·Expert Opinion on Drug Delivery·Boris Polyak, Gary Friedman
Dec 8, 2007·Journal of Pharmaceutical Sciences·J D G DuránA V Delgado
Sep 24, 2015·Advances in Colloid and Interface Science·S A Angayarkanni, John Philip
Jan 30, 2015·Chemistry : a European Journal·Swee Kuan YenSubramanian Tamil Selvan
Apr 1, 2016·Nanoscale·Laura Rodriguez-ArcoModesto T Lopez-Lopez
Jul 9, 2013·International Journal of Pharmaceutics·Alexandru Mihai GrumezescuCarmen Mariana Chifiriuc
Aug 1, 2014·The Science of the Total Environment·Bahngmi JungBrent Sleep
Aug 1, 2015·Macromolecular Bioscience·Thomas HeinzeAndreas Koschella
Mar 11, 2018·Scientific Reports·M Rezaa MohammadiJayakumar Rajadas
Apr 4, 2021·Journal of Biomedical Materials Research. Part a·Yana G ToropovaKamil G Gareev
Jun 11, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Modesto T López-LópezFernando González-Caballero
Nov 9, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Shu ChenHui-Zhou Liu

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