PMID: 8612329Nov 21, 1995Paper

Coloboma hyperactive mutant exhibits delayed neurobehavioral developmental milestones

Brain Research. Developmental Brain Research
C J HeyserL H Gold

Abstract

The coloboma mutation (Cm) is a neutron-irradiation induced gene deletion located on the distal portion of mouse chromosome 2. This deletion region includes a gene encoding the synaptic vesicle docking fusion protein, synaptosomal-associated protein of 25 kDa (SNAP-25). The resulting mutation is semi-dominant with heterozygote mice exhibiting a triad of phenotypic abnormalities that comprise profound spontaneous hyperactivity, head bobbing and a prominent eye dysmorphology. Because the expression pattern of two SNAP-25 isoforms begins to change during the first postnatal week, neurobehavioral developmental milestones were examined in order to determine if the expression of the coloboma behavioral phenotype could be detected during this period of postnatal development. The early classification of coloboma mutant offspring may help to further describe the penetrance of this mutation as well as the contribution of developmental changes to the adult behavioral phenotype. The coloboma mutation resulted in delays in some tests of complex motor skills including righting reflex and bar holding. In addition, coloboma mutants were characterized by body weight differences (first appearance day 7) and hyperreactivity to touch (day 11) and ...Continue Reading

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Citations

Mar 25, 2011·Attention Deficit and Hyperactivity Disorders·Thomas A SontagKlaus W Lange
Nov 21, 1995·Brain Research. Developmental Brain Research·C J HeyserL H Gold
Nov 19, 2003·European Journal of Pharmacology·David A Keays, Patrick M Nolan
Jun 6, 2003·Neuroscience and Biobehavioral Reviews·Albert Hung Choy Wong, Hubert H M Van Tol
Apr 2, 2003·Brain Research. Brain Research Reviews·Eugen DavidsRoss J Baldessarini
Oct 30, 2001·Behavioural Brain Research·J P HatcherA J Hunter
Dec 7, 2000·Neurotoxicology and Teratology·M G PauleF X Castellanos
Jan 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vilte E BarakauskasWilliam G Honer
May 25, 2006·European Journal of Human Genetics : EJHG·Sofia I H Godinho, Patrick M Nolan
Jun 1, 2010·Médecine sciences : M/S·Diane Purper-OuakilMichel Simonneau
Feb 4, 2011·Pediatric Research·Diane Purper-OuakilMichel Simonneau
Oct 15, 2011·Neurochemical Research·Kanyakumarika SarkarKanchan Mukhopadhyay
Feb 10, 2016·Journal of Neural Transmission·Renata Basso CupertinoNina Roth Mota
Feb 13, 2007·Neurobiology of Disease·Xueliang Fan, Ellen J Hess
Feb 12, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Holly R Robertson, Guoping Feng
Jun 14, 2005·Biological Psychiatry·Terje SagvoldenMehdi Farshbaf
Jan 24, 2009·Annals of the New York Academy of Sciences·Irene CorradiniMichela Matteoli
Feb 9, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Aaron J BobbJudith L Rapoport
Jan 29, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Renata Basso CupertinoNina Roth Mota
Feb 6, 2017·Neuroscience and Biobehavioral Reviews·Marieke KleinBarbara Franke
Aug 9, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Eunjoo KimKeun-Ah Cheon
Apr 23, 2008·Current Protocols in Neuroscience·Charles J Heyser
Feb 7, 2017·The Journal of Clinical Investigation·Danielle E WhittakerM Albert Basson
May 24, 2017·Molecular Neurobiology·June Bryan de la PeñaJae Hoon Cheong
Apr 3, 2018·Developmental Biology·Callum DarkRobert J Bryson-Richardson

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