Colocalization error between the scanning laser ophthalmoscope infrared reflectance and optical coherence tomography images of the heidelberg spectralis

Retina
Sritatath VongkulsiriRichard F Spaide

Abstract

To examine the colocalization error between the infrared reflectance (IR) scanning laser ophthalmoscope (SLO) and spectral domain optical coherence tomography (SD-OCT) images of the Heidelberg Spectralis. The IR and corresponding horizontal raster SD-OCT images were compared in 10 healthy volunteers examined with 3 Heidelberg Spectralis + OCT instruments. The center points of retinal vessels selected by random uniform sampling in scanning laser ophthalmoscope-IR images were compared with colocalizing points in corresponding SD-OCT images by two masked readers. The error of colocalization was measured in the SD-OCT image. The point positions were recorded using Cartesian coordinates measured in microns. The error of colocalization was evaluated using a fixed-effects generalized least squares regression model with location and instrument as predictor variables. A total of 1,617 points in the IR and SD-OCT images were analyzed, and the mean error of colocalization was 42.2 ± 32.4 μm. The Heidelberg Spectralis instrument used was not a significant predictor of colocalization error (P = 0.15). The colocalization errors were negatively correlated with x-coordinate position (P < 0.001). There is a mean colocalization error between the...Continue Reading

References

Nov 22, 1991·Science·D HuangC A Puliafito
Mar 1, 1995·Archives of Ophthalmology·M R HeeJ G Fujimoto
Jun 23, 2011·Investigative Ophthalmology & Visual Science·Mahsa A SohrabAmani A Fawzi
Jan 10, 2012·Investigative Ophthalmology & Visual Science·Giuseppe QuerquesEric H Souied

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