PMID: 7528516Jan 1, 1994Paper

Colocalization of acidic and basic fibroblast growth factor (FGF) in human placenta and the cellular effects of bFGF in trophoblast cell line JEG-3

Growth Factors
R A FerrianiS K Smith

Abstract

The placenta undergoes extensive angiogenesis and cellular proliferation to establish adequate blood supply to the fetus. The aim of this study was to compare and contrast the immunolocalization of acidic and basic fibroblast growth factor (FGF) in both first trimester and term placenta and gestational decidua. Human choriocarcinoma cell line JEG-3 were employed as a model of cytotrophoblast and the effect of basic FGF on cell proliferation and phospholipase C and D activation investigated. Basic FGF-immunoreactivity (IR) was detected in or around cytotrophoblast cells and in extravillous trophoblast in first trimester placenta by immunohistochemistry using primary polyclonal rabbit antibodies. Identical staining patterns were produced by acidic FGF antibodies indicating colocalization of acidic FGF and basic FGF. At term, weaker and more diffuse staining was seen in the syncytiotrophoblast surrounding the placenta villi and strong staining was present in the smooth muscle cells of mid and large size placental vessels and in some endothelial cells. Endothelial cells and extravillous trophoblast stained strongly within the decidua at first trimester, whereas the glandular epithelium was weakly stained. Basic FGF induced [3H]thym...Continue Reading

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Citations

May 2, 2002·Molecular Reproduction and Development·G RajashekharY C Wong
Oct 8, 2005·Angiogenesis·Berthold Huppertz, Louis L H Peeters
Apr 12, 2011·Folia Histochemica Et Cytobiologica·M ChruscielA Andronowska
Jun 19, 2007·Acta histochemica·Ramazan DemirBerthold Huppertz
Mar 3, 2004·Journal of Biochemical and Molecular Toxicology·María S SouzaAna M Pechén de D'Angelo
Mar 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Eyal Y AntebySimcha Yagel
Apr 1, 1995·Placenta·T WheelerF W Anthony
Apr 21, 1998·Placenta·V JokimaaL Anttila
Jul 31, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·L SeidmannC J Kirkpatrick
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Jan 7, 2004·Journal of the Society for Gynecologic Investigation·D W BurleighT G Golos
Nov 4, 2017·Journal of Molecular Endocrinology·Yingchun LiEmily J Su
Oct 26, 2005·Protein Engineering, Design & Selection : PEDS·Heidi A EricksonChristopher A Pennell

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