Colocalization of antigen-specific B and T cells within ectopic lymphoid tissue following immunization with exogenous antigen.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jason S WeinsteinWestley H Reeves

Abstract

Chronic inflammation promotes the formation of ectopic lymphoid tissue morphologically resembling secondary lymphoid tissues, though it is unclear whether this is a location where Ag-specific immune responses develop or merely a site of lymphocyte accumulation. Ectopic lymphoid tissue formation is associated with many humoral autoimmune diseases, including lupus induced by tetramethylpecadentane in mice. We examined whether an immune response to 4-hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin (NP-KLH) and NP-OVA develops within ectopic lymphoid tissue ("lipogranulomas") induced by tetramethylpecadentane in C57BL/6 mice. Following primary immunization, NP-specific B cells bearing V186.2 and related heavy chains as well as lambda-light chains accumulated within ectopic lymphoid tissue. The number of anti-NP-secreting B cells in the ectopic lymphoid tissue was greatly enhanced by immunization with NP-KLH. Remarkably, the H chain sequences isolated from individual lipogranulomas from these mice were diverse before immunization, whereas individual lipogranulomas from single immunized mice had unique oligo- or monoclonal populations of presumptive NP-specific B cells. H chain CDR sequences bore numerous replacement mutations...Continue Reading

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Citations

Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dina C NacionalesWestley H Reeves
Mar 20, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason S WeinsteinWestley H Reeves
Jul 13, 2017·The Journal of Experimental Medicine·Kristin M S SchroederRaul M Torres
Aug 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Wenqian ZhangFubin Li
Aug 2, 2012·Cancer Research·Arcadi CipponiNicolas van Baren
Aug 25, 2009·Trends in Immunology·Westley H ReevesLi Lu

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