PMID: 9655617Jul 9, 1998Paper

Colocalization of Bcl-2 and 4-hydroxynonenal modified proteins in microglial cells and neurons of rat brain following transient focal ischemia

Neuroscience Letters
T UrabeY Mizuno

Abstract

Bcl-2 has a role in suppressing the production of reactive oxygen species and lipid peroxidation. To explore the in situ localization of 4-hydroxy-2-nonenal (HNE)-modified proteins and the Bcl-2 oncoprotein, we used double immunofluorescence labeling and confocal imaging in the rat brain after 3 h of middle cerebral artery (MCA) occlusion followed by reperfusion. Immunoreactivity for HNE or Bcl-2 was not detected at 1 h, but appeared in some intact neurons in the boundary between the infarcted and non-infarcted zones at 12 h. At 48 h, HNE-positive microglia were colocalized with Bcl-2 in the infarcted area and the boundary zone. Bcl-2 may play an important role in the antioxidant system promoting survival of the neurons and activated microglia following reperfusion injury.

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Citations

Sep 24, 1999·Journal of Neuroscience Research·A J Bruce-Keller
Aug 2, 2003·Molecular Aspects of Medicine·Kamelija Zarkovic
Oct 29, 2003·Toxicology Letters·Koichi UemuraKen-ichi Yoshida
Jul 25, 2009·Antioxidants & Redox Signaling·Rao Muralikrishna Adibhatla, James Franklin Hatcher
Nov 17, 2010·Biochemistry. Biokhimii︠a︡·E E Dubinina, V A Dadali
Jun 27, 2006·The AAPS Journal·Rao Muralikrishna AdibhatlaR J Dempsey
Jul 6, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Dae Young YooJung Hoon Choi
Jan 31, 2006·Free Radical Biology & Medicine·Rao Muralikrishna Adibhatla, J F Hatcher
May 9, 2001·Biochimica Et Biophysica Acta·M J Picklo, T J Montine
Nov 18, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E McCrackenD Dewar
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K HorsburghJ A Nicoll
Sep 15, 2010·Free Radical Research·Anne Negre-SalvayreNeven Zarkovic

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