PMID: 9437742Jan 23, 1998Paper

Colocalization of inhibitory mediators, NO, VIP and galanin, in canine enteric nerves

Peptides
Y F WangE E Daniel

Abstract

The colocalization of three putative inhibitory mediators of enteric nerves, vasoactive intestinal peptide (VIP), galanin (GAL) and nitric oxide synthase (nNOS), was examined in the myenteric plexus of canine antrum, intestine and colon. Many ileal and colonic neurons contained nNOS-immunoreactive (nNOS-IR) activity with some also containing VIP-IR; only a few neurons also contained GAL-IR. Ileal and colonic VIP-IR nerves often appeared to be interneurons innervating nNOS nerves. Many antral neurons contained VIP-IR with nearly all also containing GAL-IR. A few also contained nNOS-IR. The predominance of nNOS-IR neurons relative to VIP-IR and GAL-IR neurons in the ileal and colonic, but not the antral, myenteric plexus is consistent with NO being the primary inhibitory mediator in the intestine but not in the antrum.

References

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Citations

Dec 22, 1999·Microscopy Research and Technique·E E Daniel, Y F Wang
Jun 29, 1999·British Journal of Pharmacology·J Jury, E E Daniel
Feb 5, 2002·Canadian Journal of Physiology and Pharmacology·J JuryE E Daniel
Jul 8, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E E DanielM Mori
Dec 3, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·V E CowlesS K Sarna
Oct 3, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C ShibataI Sasaki
Oct 29, 2005·The Journal of Comparative Neurology·Elizabeth A H BeckettSean M Ward
Oct 17, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C SeveriG Delle Fave
Aug 28, 2004·Autonomic Neuroscience : Basic & Clinical·Zhong LinEva Ekblad
Sep 15, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·E E DanielY F Wang

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