Colocation of the Polymyxin Resistance Gene mcr-1 and a Variant of mcr-3 on a Plasmid in an Escherichia coli Isolate from a Chicken Farm

Antimicrobial Agents and Chemotherapy
Rong XiangHong-Ning Wang

Abstract

A colistin-resistant Escherichia coli isolate from a commercial poultry farm in China carried two colistin resistance genes, mcr-1 and variant of mcr-3, in an IncP plasmid. The variant of the mcr-3 gene, named mcr-3.11, encoded two amino acid substitutions compared with the mcr-3 gene. A novel genetic structure, ISKpn40-mcr-3-dgkA-ISKpn40, might be the key element mediating the translocation of mcr-3 through the formation of a circular form. The mcr-1 and mcr-3 genes, which are colocated on a plasmid, might pose a huge threat to public health.

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Citations

Feb 23, 2019·The Journal of Antimicrobial Chemotherapy·Ruichao LiLi Bai
Jun 19, 2019·Antimicrobial Agents and Chemotherapy·Pei ZhangRuichao Li
Dec 19, 2019·Frontiers in Microbiology·Linda HadjadjJean-Marc Rolain
Jul 28, 2018·The Journal of Antimicrobial Chemotherapy·Sally R PartridgeBasil Britto Xavier
Dec 17, 2020·Frontiers in Veterinary Science·David Ortega-ParedesChristian Vinueza-Burgos
Jul 15, 2020·Antimicrobial Agents and Chemotherapy·Yu-Zhang HeJian Sun
Apr 12, 2021·Molecular Biology Reports·Nadheema Hammood HusseinJumaah Dakel Hussein

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