PMID: 25749516Mar 10, 2015Paper

ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients

Oncotarget
Teodoro VargasAna Ramírez de Molina

Abstract

Lipid metabolism plays an essential role in carcinogenesis due to the requirements of tumoral cells to sustain increased structural, energetic and biosynthetic precursor demands for cell proliferation. We investigated the association between expression of lipid metabolism-related genes and clinical outcome in intermediate-stage colon cancer patients with the aim of identifying a metabolic profile associated with greater malignancy and increased risk of relapse. Expression profile of 70 lipid metabolism-related genes was determined in 77 patients with stage II colon cancer. Cox regression analyses using c-index methodology was applied to identify a metabolic-related signature associated to prognosis. The metabolic signature was further confirmed in two independent validation sets of 120 patients and additionally, in a group of 264 patients from a public database. The combined analysis of these 4 genes, ABCA1, ACSL1, AGPAT1 and SCD, constitutes a metabolic-signature (ColoLipidGene) able to accurately stratify stage II colon cancer patients with 5-fold higher risk of relapse with strong statistical power in the four independent groups of patients. The identification of a group of 4 genes that predict survival in intermediate-stage...Continue Reading

References

Jun 26, 2003·Cancer Science·Young Kwan SungMoonkyu Kim
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yixin WangDavid Atkins
Jun 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Al B BensonDaniel G Haller
Oct 7, 2004·Journal of the National Cancer Institute·Jessica B O'ConnellClifford Y Ko
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven EschrichTimothy J Yeatman
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alain BarrierSandrine Dudoit
Dec 7, 2007·Cancer Biology & Therapy·Chuangying HuShaofeng Wang
Dec 18, 2007·Lancet·UNKNOWN Quasar Collaborative GroupDavid J Kerr
Dec 17, 2009·World Journal of Gastroenterology : WJG·Miroslav ZavoralPremysl Fric
Nov 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ramon SalazarRob Tollenaar
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Sep 29, 2011·Molecular Cancer Research : MCR·Urvashi V RoongtaBrent A Rupnow
Nov 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard G GrayDavid J Kerr
May 25, 2012·The FEBS Journal·Claudio R Santos, Almut Schulze
Jun 15, 2012·Journal of Gastroenterology and Hepatology·Sam Al-SohailyJanindra Warusavitarne
Sep 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anita SveenRagnhild A Lothe

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Citations

Sep 29, 2017·Nutrients·Cristina Aguirre-PortolésAna Ramírez de Molina
Feb 16, 2018·Oncogene·Rita ManciniGennaro Ciliberto
Feb 22, 2018·Oncotarget·Lara P FernándezAna Ramírez de Molina
Jan 26, 2016·Oncogenesis·S Beloribi-DjefafliaF Guillaumond
Jan 28, 2019·Lipids in Health and Disease·Alicja PakietAdriana Mika
Mar 14, 2018·Journal of Experimental & Clinical Cancer Research : CR·Hui RanQing Su
Dec 13, 2018·BMC Genomics·Jorge Martinez-RomeroJavier De Las Rivas
Jul 3, 2019·The Journal of Clinical Investigation·Yihai Cao
Jul 10, 2019·Cancers·Zuzanna Tracz-Gaszewska, Pawel Dobrzyn
Nov 17, 2020·Frontiers in Oncology·Lara P FernándezAna Ramírez de Molina
Feb 11, 2021·International Journal of Molecular Sciences·Leonor Jacobo-AlbaveraTeresa Villarreal-Molina
Nov 22, 2020·Molecular Aspects of Medicine·Elena PiccininAntonio Moschetta
Apr 4, 2021·International Journal of Molecular Sciences·Aleksandra ZeljkovicBratislav Trifunovic

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