Colon cancer cells: pro-invasive signalling

The International Journal of Biochemistry & Cell Biology
Delphine DebruyneAncy Leroy

Abstract

Colon cancer results from erroneous renewal of the enteric epithelium. Mutations in stem cells, or their proliferative progenitors, cause accumulation of cells that invade into the stroma and continue to divide rather than migrating on top of the basement membrane prior to entering into apoptosis. Many of these changes in invasive activity appear to be related to the invasion-suppressor role of E-cadherin. We have also investigated Listeria monocytogenes and other enteric bacteria, since these bacteria stimulate invasion through the production of a beta-casein-derived 13-amino acid peptide which is produced by enzymes present in the colon cancer ecosystem. The pro-invasive 13-amino acid peptide signals via small guanosine triphosphatases, which modulate the actin cytoskeleton, and via phosphorylation of the delta opioid receptor. The pro-invasive activity of this peptide is neutralized by the delta opioid receptor antagonist, naloxone. Since the delta opioid receptor belongs to the family of G protein-coupled receptors, implicated in colon cancer cell invasion signalling pathways, it is tempting to speculate that opioids could play a role in mediating this trait of malignant tumours.

References

Feb 12, 2002·Nature Cell Biology·Yasuyuki FujitaWalter Birchmeier
May 11, 2002·Nature Reviews. Cancer·Livio Trusolino, Paolo M Comoglio
Nov 21, 2002·Journal of the National Cancer Institute·Céu FigueiredoManuel Sobrinho-Simões
Mar 29, 2003·Physiological Reviews·Marc Mareel, Ancy Leroy
Jul 8, 2003·The Journal of Pathology·Olivier De Wever, Marc Mareel
Jun 16, 2004·Cancer Metastasis Reviews·Jakub Fichna, Anna Janecka
Sep 7, 2004·The International Journal of Developmental Biology·Héctor PeinadoAmparo Cano
Sep 7, 2004·The International Journal of Developmental Biology·Lara D M Derycke, Marc E Bracke
Mar 26, 2005·Science·Freddy Radtke, Hans Clevers
May 11, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Lecuit

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