Colon cancer proliferating desulfosinigrin in wasabi (Wasabia japonica)

Nutrition and Cancer
Marvin J WeilMuraleedharan G Nair

Abstract

A reduced incidence of different types of cancer has been linked to consumption of Brassica vegetables, and there is evidence that glucosinolates (GSLs) and their hydrolysis products play a role in reducing cancer risk. Wasabi (Wasabia japonica) and horseradish (Armoracia rusticana), both Brassica vegetables, are widely used condiments both in Japanese cuisine and in the United States. Desulfosinigrin (DSS) (1) was isolated from a commercially available wasabi powder and from fresh wasabi roots. Sinigrin (2) was isolated from horseradish roots. DSS and sinigrin were evaluated for their inhibitory effects on cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, on lipid peroxidation, and on the proliferation of human colon (HCT-116), breast (MCF-7), lung (NCIH460), and central nervous system (CNS, SF-268) cancer cell lines. DSS did not inhibit COX enzymes or lipid peroxidation at 250 microg/ml. Sinigrin inhibited lipid peroxidation by 71% at 250 microg/ml. However, DSS promoted the growth of HCT-116 (colon) and NCI H460 (lung) human cancer cells as determined by the MTT assay in a concentration-dependent manner. At 3.72 microg/ml, a 27% increase in the number of viable human HCT-116 colon cancer cells was observed; the ...Continue Reading

References

Jan 1, 1983·Critical Reviews in Food Science and Nutrition·G R FenwickW J Mullin
Jul 1, 1993·Mutation Research·S R Musk, I T Johnson
Aug 4, 1998·International Journal of Cancer. Journal International Du Cancer·M HiroseT Shirai
Dec 20, 1999·Journal of Agricultural and Food Chemistry·J B GardinerV Borek
Jan 6, 2000·Journal of the National Cancer Institute·J H CohenJ L Stanford
Apr 8, 2000·Free Radical Biology & Medicine·M MurataS Kawanishi
Feb 21, 2002·Journal of Agricultural and Food Chemistry·Maria Paola GermanòChiara Costa
Sep 19, 2002·Nutrition and Cancer·Alan R Kristal, Johanna W Lampe
Feb 1, 2003·Trends in Pharmacological Sciences·Kotha Subbaramaiah, Andrew J Dannenberg
Oct 25, 2003·Life Sciences·Bolleddula JayaprakasamMuraleedharan G Nair
Jul 1, 2002·Environmental Health and Preventive Medicine·Bandaru S Reddy

❮ Previous
Next ❯

Citations

Feb 28, 2015·European Journal of Nutrition·Shu-Wen HsuanFen-Pi Chou
Oct 13, 2007·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·H NathuesP E N Givisiez
Jul 14, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Ken Steen PedersenJens Peter Nielsen
Sep 21, 2018·Journal of Natural Products·Chung Sub KimKang Ro Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.