Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Boushra DalileLukas Van Oudenhove

Abstract

Short-chain fatty acids (SCFAs) are products of microbial fermentation of dietary fiber in the colon and may mediate microbiota-gut-brain communication. However, their role in modulating psychobiological processes that underlie the development of stress- and anxiety-related disorders is not mechanistically studied in humans. In this triple-blind, randomized, placebo-controlled intervention trial, we examine in a parallel group design the effects of 1-week colonic SCFA-mixture delivery in doses equivalent to fermentation of 10 g or 20 g of arabinoxylan oligosaccharides on responses to psychosocial stress and fear tasks in 66 healthy men. We demonstrate that low and high doses of SCFAs significantly attenuate the cortisol response to psychosocial stress compared to placebo. Both doses of SCFAs increase serum SCFA levels and this increase in circulating SCFAs co-varies significantly with the attenuation of the cortisol response to psychosocial stress. Colonic SCFA delivery does not modulate fecal SCFA concentrations, serum brain-derived neurotrophic factor, cortisol awakening response, fear learning and extinction, or subjective mood ratings. These results demonstrate that colon-delivered SCFAs modulate hypothalamic-pituitary-adre...Continue Reading

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Citations

Oct 24, 2020·Nature Reviews. Microbiology·Livia H MoraisSarkis K Mazmanian
Feb 11, 2021·International Journal of Molecular Sciences·Davide BanfiAndreina Baj
Oct 18, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Estefany I Medina-ReyesJosé Pedraza-Chaverri
Mar 2, 2021·Experimental Biology and Medicine·Kirsten BerdingJohn F Cryan
Apr 14, 2021·Psychoneuroendocrinology·Boushra DalileLukas Van Oudenhove
May 3, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Camille AmadieuNathalie M Delzenne
Sep 12, 2021·The Journal of Clinical Endocrinology and Metabolism·Charlotte Bayer ChristiansenJens Juul Holst
Aug 12, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Zeinab FarhatErikka Loftfield
Nov 24, 2021·Human Brain Mapping·Caitlin V HallLuca Cocchi

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Methods Mentioned

BETA
histone acetylation
acetylation

Clinical Trials Mentioned

NCT03688854

Software Mentioned

SAS

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