Colon targeted curcumin microspheres laden with ascorbic acid for bioavailability enhancement

Journal of Microencapsulation
Preeti G Karade, Namdeo R Jadhav

Abstract

An objective of the present study was to prepare colon-specific microspheres of curcumin (CUR) containing ascorbic acid (AA) for improved oral bioavailability. 32 factorial design was used to optimise chitosan microspheres (CSMS) containing CUR and AA. Subsequently, optimised CSMS were coated with Eudragit S-100, for delivery to colon. In vitro drug release, in vivo pharmacokinetics, and organ distribution studies were performed in Albino Wistar rats. Stabilisation of CUR in alkaline pH was successfully guarded by AA to the extent 98.5-100%. Results revealed complete amorphisation/molecular dispersion of CUR. Bioavailability enhancement of CUR and 90% of MS in colon at the end of 8 h in animals, deciphered successful design of colon-specific CUR MS. It can be concluded that AA in MS shielded the degradation of CUR. The developed double coat MS could be considered as a promising colon-targeted system for CUR aiming bioavailability enhancements.

References

Jul 22, 1993·The New England Journal of Medicine·D J HunterW C Willett
Aug 1, 1997·Journal of Pharmaceutical and Biomedical Analysis·Y J WangJ K Lin
Nov 9, 2000·Drug Development and Industrial Pharmacy·M K Yeh
Jun 13, 2001·Biochemical and Biophysical Research Communications·V G ReddyN Singh
Feb 6, 2003·Journal of the American College of Nutrition·Sebastian J PadayattyMark Levine
Apr 26, 2005·International Journal of Pharmaceutics·Yan WuShoukuan Fu
Aug 6, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R A SharmaW P Steward
Nov 23, 2006·International Journal of Pharmaceutics·Kuntal MaitiPulok K Mukherjee
Apr 3, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kuo-Yi YangTung-Hu Tsai
Apr 6, 2007·AAPS PharmSciTech·Amol PahariaGovind P Agrawal
Sep 29, 2007·Biochemical Pharmacology·Ajay GoelBharat B Aggarwal
Apr 18, 2008·The Journal of Pharmacy and Pharmacology·Ziyaur RahmanMichael A Repka
Jun 13, 2008·Chemico-biological Interactions·Tuba Ak, Ilhami Gülçin
Jul 26, 2008·Molecular Nutrition & Food Research·Isabel VillegasCatalina Alarcón de la Lastra
Sep 18, 2009·Journal of Agricultural and Food Chemistry·Makoto TakahashiKoji Wada
Jan 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Natthakitta SuwannateepJisnuson Svasti
Jan 23, 2013·BioFactors·Subash C GuptaBharat B Aggarwal
Apr 17, 2016·European Journal of Cell Biology·Ana Salomé PiresMaria Filomena Botelho
Sep 16, 2017·Journal of Food and Drug Analysis·Ayodele Jacob AkinyemiIsrael Olayide

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Citations

Sep 11, 2019·Nutrients·Michele Dei Cas, Riccardo Ghidoni
Aug 28, 2020·Frontiers in Medicine·Farhana Rumzum BhuiyanMahmudul Hasan

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