Colon vs small bowel rejection after total bowel transplantation in a pig model

Transplant International : Official Journal of the European Society for Organ Transplantation
R E NakhlehR W Gruessner

Abstract

With the advent of FK 506, small bowel transplantation has become clinically feasible. Both clinically and experimentally, jejunal and ileal biopsies are used for early diagnosis of rejection. More recently, the colon, in addition to the small bowel, has been transplanted to decrease the high incidence of diarrhea after small bowel transplantation. A Bishop-Koop ileostomy allows biopsies on a regular basis, but the diagnosis of rejection remains a problem after takedown of the ileostomy. Rejection of the ileum is more frequent and more severe than rejection of the jejunum or the colon. Colon biopsy after ileostomy takedown would not rule out rejection of the ileum.

References

Mar 27, 1994·Transplantation·S TodoA J Demetris
Sep 1, 1995·Annals of Surgery·S TodoT E Starzl
Nov 1, 1993·Transplantation·R W GruessnerD E Sutherland
Jan 1, 1993·Microsurgery·H Plapler, Z Cohen

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Citations

Oct 21, 1998·Journal of Pediatric Gastroenterology and Nutrition·L SigurdssonS A Kocoshis
Jul 10, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Pablo D UvaDomingo H Casadei

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