Colonic and jejunal motor disturbances after colonic antigen challenge of sensitized rat

Gastroenterology
M R OliverR B Scott

Abstract

Inflammation in the colon may alter motility in the proximal gut and potentiate clinical symptoms. The aim of this study was to characterize the effect of colonic anaphylaxis on local (colonic) and remote (small intestinal) motility and identify the mechanism and mediators involved. Rats were sensitized by intraperitoneal injection of 10 microg egg albumin and surgically prepared with electrodes in jejunum and colon and a colostomy tube. Colonic and jejunal myoelectric activity were recorded in fasted animals before and after colonic antigen challenge without and then after pretreatment with specific antagonists. Colonic antigen challenge of sensitized rats was associated with significant (1) increase in colonic myoelectric spike activity, (2) disruption of fasting jejunal motility and initiation of aborally propagating spike complexes, and (3) increase in plasma rat mast cell protease II levels with a decrease in granulated mast cells in colon but not jejunum. The myoelectric disturbance in both colon and jejunum was inhibited significantly by pretreatment with atropine and hexamethonium, doxantrazole, cyclooxygenase, and lipoxygenase inhibitors. Methysergide inhibited only the jejunal disturbance. Colonic antigen challenge of...Continue Reading

Citations

Aug 21, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ralf G Heine
May 6, 2004·Current Opinion in Allergy and Clinical Immunology·Ralf G Heine
Mar 24, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A C AubeJ P Galmiche
Apr 14, 2012·The Journal of Veterinary Medical Science·Yukitoshi MakimuraHirokazu Tsubone
Sep 23, 2019·The Journal of Physiological Sciences : JPS·Tao ZhangYasutaka Kurata
Oct 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·R B ScottK A Sharkey
Jun 1, 2018·Mediators of Inflammation·E M LennonA J Moeser
Oct 2, 1998·The American Journal of Physiology·R B ScottK A Sharkey

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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.