Colonic antigen administration induces significantly higher humoral levels of colonic and vaginal IgA, and serum IgG compared to oral administration

Vaccine
Emma L McConnellSudaxshina Murdan

Abstract

It was hypothesised that different immune responses would be obtained following oral and colonic antigen administration, due to the significant differences in the immune environments of the colon and that of the small intestine. Antigen administration to the mouse colon (via the rectum) was found to generate different profiles of immune responses compared to oral administration (by gavage). Serum IgG and IgA levels in faecal and colonic extracts and in the vaginal wash were significantly higher following colonic administration of soluble (plus cholera toxin B subunit adjuvant) or encapsulated (in microspheres) antigen while smaller differences were seen in the small intestinal IgA levels. This reflects the compartmentalisation within the common mucosal immune system and suggests that the colon may be an appropriate vaccination target for diseases of the colon, and for sexually and vertically transmitted diseases. Antigen was also administered rectally and intramuscularly as controls. Colonic administration was superior to rectal administration, possibly due to the greater amounts of lymphoid tissue in the colon, although the immune response profiles were similar.

References

Apr 1, 1985·The Journal of Pharmacy and Pharmacology·M JayA R Mlodozeniec
Mar 1, 1986·Histopathology·A D O'Leary, E C Sweeney
Aug 1, 1995·Scandinavian Journal of Immunology·G Boll, J Reimann
Nov 5, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·M IgartuaJ L Pedraz
Mar 5, 2003·Vaccine·Tosca G M LauterslagerLuuk A T Hilgers
Nov 25, 2004·Advanced Drug Delivery Reviews·Tazio StorniPål Johansen
Sep 16, 2005·Drugs·Abdul W Basit
Dec 20, 2007·The Journal of Pharmacy and Pharmacology·Emma L McConnellSudaxshina Murdan

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Citations

May 20, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hamid A MerchantAbdul W Basit
Feb 26, 2009·International Reviews of Immunology·Thorsten Demberg, Marjorie Robert-Guroff
Jun 27, 2009·Journal of Drug Targeting·Emma L McConnellAbdul W Basit
Nov 19, 2008·Journal of Drug Targeting·Abdul W BasitEmma L McConnell
Oct 12, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hamid A MerchantSudaxshina Murdan
Jul 8, 2008·International Journal of Pharmaceutics·Emma L McConnellAbdul W Basit
Oct 1, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Chiara SandoloNicolas Tsapis
Mar 16, 2013·Gut Microbes·Qing Zhu, Jay A Berzofsky
Feb 24, 2017·Clinical and Vaccine Immunology : CVI·Luis M de la MazaRobert C Brunham
Jun 3, 2021·Biomedicines·Vipul YadavAbdul W Basit

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