Colonic carcinogenesis along different genetic routes: glycophenotyping of tumor cases separated by microsatellite instability/stability.

Histochemistry and Cell Biology
Johannes GebertHans-Joachim Gabius

Abstract

Different genetic routes account for colonic carcinogenesis. However, when analyzing colon cancer specimens, separation into different groups based on genetic alterations is commonly not performed. Thus, we here initiate the comparative phenotyping considering microsatellite instability/stability for clinical specimens. The focus is given to glycan epitopes, expression of which is known to be modulated by signal-transducing proteins that act as key regulators of normal colon epithelial growth and differentiation. In addition to six plant lectins used as sensors, the presence of two adhesion/growth-regulatory galectins is studied. Overall, a considerable level of intra- and interindividual heterogeneity is revealed. Alterations in the proportion of stained cells between tumor-adjacent and malignant epithelia concerned plant lectins, which bind substituted N-glycan cores, α2,6-sialylated branch ends, core 1 O-glycans and N-acetylgalactosamine. A tendency for changes was noted between microsatellite-unstable and microsatellite-stable cases for core substitution (bisected N-glycan, presence of β1,6-branching) and status of α2,6-sialylation. Statistical significance was reached for presence of galectin-3, found to be elevated in mic...Continue Reading

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Citations

May 15, 2013·Histochemistry and Cell Biology·Douglas J Taatjes, Jürgen Roth
Jun 21, 2014·Biochimica Et Biophysica Acta·Fabio Dall'OlioMariella Chiricolo
Jan 8, 2013·Expert Opinion on Therapeutic Targets·Karel SmetanaHans-Joachim Gabius
Jan 22, 2014·Diagnostic Pathology·Hans-Joachim Gabius, Klaus Kayser
Dec 25, 2019·The Journal of Experimental Medicine·María Romina GirottiGabriel A Rabinovich
Nov 6, 2015·Oncotarget·Julio Cesar Madureira de Freitas Junior, José Andrés Morgado-Díaz
Dec 22, 2016·Histochemistry and Cell Biology·Jürgen Kopitz
Oct 26, 2021·Histochemistry and Cell Biology·Herbert KaltnerAnthony Corfield

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