PMID: 11330454May 2, 2001Paper

Colonic cell proliferation, apoptosis and aberrant crypt foci development in rats given 2-amino-3-methylimidaz

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
R H DashwoodD T Horio

Abstract

Sodium-copper chlorophyllin (CHL) inhibits the formation of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced colonic aberrant crypt foci (ACF) and tumours in the F344 rat when it is given simultaneously with either carcinogen. However, CHL reportedly increased the incidence of dimethylhydrazine (DMH)-induced colon tumours in the same species when administered post-initiation. In the present study, rats were given IQ (130 mg/kg body weight, by oral gavages on alternating days) for 2 weeks, starting in experiment week 3, and one week after the final IQ dose rats received CHL treatment until the study was terminated at 16 weeks. Compared with animals given carcinogen alone, the mean number of IQ-induced ACF per colon was reduced significantly by 1% (w/v) CHL in the drinking water (P < 0.05), whereas 0.1% and 0.01% CHL had no effect. These CHL concentrations increased in a dose-related manner both the terminal deoxynucleotidyl transferase-mediated nick end labelling (TUNEL) and bromodeoxyuridine (BrdU) labelling indices in the distal colon. However, the lowest concentration tested, 0.001% CHL, increased the mean number of IQ-induced ACF per colon (P < 0.05), and increa...Continue Reading

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
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Jun 1, 1996·Japanese Journal of Cancer Research : Gann·Y HiroseH Mori
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Apr 20, 2000·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·S Franceschi

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Citations

Feb 28, 2016·Bioorganic Chemistry·Grzegorz GołuńskiJacek Piosik
Dec 12, 2003·World Journal of Gastroenterology : WJG·Lei Cheng, Mao-De Lai
Jun 21, 2003·Neural Computation·Guilherme de A BarretoStefan C Kremer
Mar 8, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Roderick H Dashwood
May 30, 2021·Bulletin of Experimental Biology and Medicine·N V EreminaA D Durnev

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