Colonic dysfunction during shigellosis

The Journal of Infectious Diseases
T ButlerJ Banwell

Abstract

To study the pathogenesis of shigella diarrhea, we evaluated 11 patients for colonic fluid and electrolyte flux. Methods used were subtraction of the fecal flow rate from the ileocecal flow rate and colonoscopic perfusion of the colon. The mean ileocecal flow rate was 0.57 ml/min compared with a mean fecal flow rate of 0.48 ml/min, and the mean of the differences showed a slight net colonic water absorption of +0.09 ml/min. With use of perfusion, these patients showed an overall mean of slight net fluid secretion by the colon of -0.04 ml/min. Seven patients restudied during convalescence showed a mean net rate of colonic water absorption of +0.65 ml/min, which was significantly greater than in the acute phase (P less than .05), and a mean ileocecal flow rate of 0.56 ml/min. Ion transport by the colon during acute shigellosis showed net secretion of K+, which changed to net absorption in convalescence (P less than .05), and a decreased absorption of Cl-, which improved in convalescence (P less than .05). Patients with extensive colitis showed more impairment of net water absorption by the colon than did patients with colitis limited to the rectosigmoid colon. These findings demonstrate that shigella diarrhea results from colonic...Continue Reading

Citations

Dec 1, 1990·Pflügers Archiv : European journal of physiology·H J Binder, P Mehta
Jul 27, 2001·Current Gastroenterology Reports·T Butler
Apr 1, 1987·Baillière's Clinical Gastroenterology·C A WankeR L Guerrant
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May 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Barbara E MurrayWilliam B Greenough
Sep 11, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas Butler
Oct 6, 2001·Gastroenterology Clinics of North America·C D Goldsweig, P A Pacheco
Sep 28, 1999·Scandinavian Journal of Gastroenterology·S HeydornP B Mortensen
Sep 28, 1999·Scandinavian Journal of Gastroenterology·S KrishnanM Mathan
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Jun 1, 1987·Microbiological Reviews·A D O'Brien, R K Holmes
Aug 24, 2021·Infection and Immunity·I-Ling ChiangThaddeus S Stappenbeck

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