Colonic electrical stimulation regulates colonic transit via the nitrergic pathway in rats.

Digestive Diseases and Sciences
Shi Liu, J D Z Chen

Abstract

Gastrointestinal electrical stimulation has been proposed for the treatment of gastrointestinal motor disorders. However, little is known about potential roles of colonic electrical stimulation (CES). The aim of this study was to evaluate the effect and mechanism of CES on colonic transit in conscious rats. Male rats (N = 14) were equipped with a pair of colonic serosal electrodes for stimulation and a catheter in the colon. Colonic transit was assessed in four randomized sessions with or without CES and with or without nitric oxide synthesis blocker, L-NNA, by calculating the output of phenol red from the anus every 10 min for 90 min. Results were as follows. (1) CES with trains of short pulses significantly enhanced colonic transit. Colonic emptying was 57.3 +/- 6.1% in the control session and 81.9 +/- 4.6% with CES at 90 min, reflecting a 43% increase. (2) L-NNA delayed colonic transit compared with saline and prevented the accelerative effect of CES on colonic transit. We conclude that CES has an excitatory effect on colonic transit and this excitatory effect may be mediated via the nitrergic pathway.

References

Mar 1, 1995·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J C Eagon, K A Kelly
Jan 1, 1994·British Journal of Pharmacology·A AlemayehuC C Chou
Aug 1, 1997·Scandinavian Journal of Gastroenterology·F KarmeliD Rachmilewitz
Mar 13, 1998·Gastroenterology·R W McCallumR A Ross
Nov 18, 2000·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·T OnagaT Sakata
Mar 21, 2003·Digestive Diseases and Sciences·Hitoshi TadaToku Takahashi
Jun 10, 2003·Diseases of the Colon and Rectum·Takeshi HirabayashiMasaki Kitajima

❮ Previous
Next ❯

Citations

Jul 14, 2006·Current Treatment Options in Gastroenterology·Jing Zhang, J D Z Chen
May 10, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xuan-Zheng Shi, Sushil K Sarna
Nov 18, 2015·Neuromodulation : Journal of the International Neuromodulation Society·Shuo ChenYuhui Du
Jan 29, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·H S Sallam, J D Z Chen
Jun 11, 2011·Obesity·Hanaa S Sallam, Jiande D Z Chen
Feb 26, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S BerdúnP Vergara
Mar 10, 2017·Expert Review of Gastroenterology & Hepatology·Jiande D Z ChenWei Wei
Aug 10, 2019·Micromachines·Po-Min WangWentai Liu
Jun 27, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Haifeng JinJieyun Yin
Sep 26, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sergio BerdúnPatri Vergara
Jun 25, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Muriel LaraucheMulugeta Million
Jan 6, 2018·Physiological Research·Lili ZhangBangmao Wang
Sep 27, 2018·Cold Spring Harbor Perspectives in Medicine·Larry MillerAnil Vegesna

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.