Colonic indole, gut bacteria metabolite of tryptophan, increases portal blood pressure in rats

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Tomasz HucMarcin Ufnal

Abstract

Portal hypertension (PH) is a potentially life-threatening condition. We investigated the effects of indole and dietary tryptophan, a substrate for gut bacterial production of indole, on portal blood pressure (PBP), portal blood flow (PBF), and arterial blood pressure (ABP) in Sprague-Dawley rats (SD) and SD with PH induced by liver cirrhosis (SD-PH). Hemodynamics were recorded in anesthetized male 28-wk-old SD and SD-PH at baseline and after the administration of either a vehicle or indole into the colon. Blood levels of tryptophan and its bacterial metabolites were evaluated using chromatography coupled with mass spectrometry. Indole at lower doses increased PBP and PBF. Indole at higher doses produced a transient increase in PBP, which was accompanied by a decrease in ABP. Portal blood levels of indole, indole-3-propionic, indole-3-lactic, and indole-3-acetic acids were higher in SD-PH, suggesting an increased gut-blood barrier permeability. Rats on a tryptophan-rich diet showed a significantly higher PBP and portal blood level of indoles than rats on a tryptophan-free diet. In conclusion, a tryptophan-rich diet and intracolonic indole increase PBP and portal blood level of indole. Rats with PH show an increased penetration ...Continue Reading

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Citations

Jul 27, 2018·Current Drug Targets·Izabella Mogilnicka, Marcin Ufnal
Oct 23, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Liam M Heaney
May 19, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dustin M LeeChristopher L Gentile
Nov 16, 2019·Pflügers Archiv : European journal of physiology·Maksymilian OnyszkiewiczMarcin Ufnal
Feb 19, 2021·Circulation Research·Huanan ShiDavid J Durgan
Jun 18, 2021·Biological Reviews of the Cambridge Philosophical Society·Prasun KumarJintae Lee
Jul 7, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Meisam BaratiFereidoun Azizi
Nov 11, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Piotr KonopelskiMarcin Ufnal

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