Colonic intra-epithelial carcinoma occurring in a hyperplastic polyp via a serrated adenoma

Pathology International
M TanakaH Kudo

Abstract

We present a case of intra-epithelial carcinoma occurring in a serrated adenoma of the colon. The pedunculated polyp, which measured 12 x 10 x 6 mm, was endoscopically removed from the ascending colon of a 78-year-old woman. Histologically, the polyp mainly consisted of serrated adenomatous glands, and had foci of intra-epithelial carcinoma at the top. Hyperplastic (metaplastic) areas were also present in both borders between the serrated adenomatous area and the surrounding normal mucosa. A sequential increase in the degree of dysplasia, and in the number of nuclei positively reactive for Ki-67 and p53 was evident from the hyperplastic areas toward the foci of carcinoma. The polyp described here may represent a carcinogenic potential of hyperplastic polyp via serrated adenoma.

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Citations

Sep 1, 2005·Digestive Diseases and Sciences·Natsuko TatsumiTakanori Hattori
Oct 27, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Angela N BartleyStanley R Hamilton
Jan 6, 2007·Histopathology·M J Mäkinen
Dec 14, 2017·BMC Gastroenterology·Daiki HiranoKazuaki Chayama
Jun 20, 2012·The American Journal of Gastroenterology·Douglas K RexJames Church
May 16, 2007·The Journal of Pathology·L G Carvajal-CarmonaI P M Tomlinson

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