Colonic mucosal expression of heat-shock proteins may have a potential prognostic value in ulcerative colitis

Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology
Abdel Raouf Abou El AzmAsem Elfert

Abstract

Ulcerative colitis (UC) is a lifelong, chronic, progressive, and relapsing inflammatory disease. Endoscopy with biopsies is the mainstay in diagnosis and assessment. The development of biomarkers is important for the diagnosis and follow-up of UC. We investigated the expression of molecular chaperones/heat-shock proteins (HSP70 and HSP90) in relation to the grades of inflammation and dysplasia in patients with UC before and after treatment. A total of 104 naïve patients with UC of varying severity were admitted to the Department of Tropical Medicine and Infectious Diseases, Tanta University Hospital. Ten biopsies from the healthy mucosa of patients with irritable bowel syndrome (IBS) served as a control. Disease activity was assessed clinically using the Mayo score system. Endoscopic mucosal biopsies were taken at diagnosis and 6 months after treatment. Histopathological activity was graded for inflammation and dysplasia. Immunohistochemistry was used to determine the percentage of cells positive for HSPs. The results were expressed in a semiquantitative scale. The expression of both HSP70 and HSP90 increased in patients with UC at the time of disease activity, and it decreased after treatment and remission. There was a signifi...Continue Reading

References

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Mar 21, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shien HuEugene B Chang
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Feb 3, 2012·European Journal of Histochemistry : EJH·G TomaselloF Cappello

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Citations

Jul 15, 2015·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Emanuele SinagraFrancesco Cappello
Jul 19, 2016·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Alper SozutekAhmet Cennet
Aug 11, 2016·Inflammatory Bowel Diseases·Dylan K McDanielIrving C Allen

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