Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity

The Journal of Immunology : Official Journal of the American Association of Immunologists
Sun-Young ChangMi-Na Kweon

Abstract

Although the mucosal and the systemic immune compartments are structurally and functionally independent, they engage in cross-talk under specific conditions. To investigate this cross-talk, we vaccinated mice with tetanus toxoid together with cholera toxin with s.c. priming followed by intrarectal (IR) boosting. Interestingly, higher numbers of Ag-specific IgA and IgG Ab-secreting cells (ASCs) were detected in the lamina propria of the large intestine of mice vaccinated s.c.-IR. Ag-specific ASCs from the colon migrated to SDF-1alpha/CXCL12 and mucosae-associated epithelial chemokine/CCL28, suggesting that CXCR4(+) and/or CCR10(+) IgA ASCs found in the large intestine after s.c.-IR are of systemic origin. In the colonic patches-null mice, IgA ASCs in the large intestine were completely depleted. Furthermore, the accumulation of IgA ASCs in the colonic patches by inhibition of their migration with FTY720 revealed that colonic patches are the IgA class-switching site after s.c.-IR. Most interestingly, s.c.-IR induced numbers of Ag-specific IgA ASCs in the large intestine of TLR2(-/-), TLR4(-/-), MyD88(-/-), and TRIF(-/-) mice that were comparable with those of wild-type mice. Taken together, our results suggest the possibility tha...Continue Reading

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Aug 22, 2008·Nature·Koji AtarashiKiyoshi Takeda
May 11, 2010·Immunological Investigations·Per Brandtzaeg
Jan 28, 2009·Nature Reviews. Immunology·J Rodrigo MoraUlrich H von Andrian
Nov 12, 2014·World Journal of Gastroenterology : WJG·Rowann BowcuttSheena Margaret Cruickshank
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sun-Young ChangMi-Na Kweon
Oct 19, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sae-Hae KimYong-Suk Jang
Oct 14, 2009·The Journal of Experimental Medicine·Takahiro NagatakeHiroshi Kiyono
Jul 11, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Young-In KimSun-Young Chang
Dec 12, 2020·International Immunopharmacology·Jun-Xiang ShuXian-Hui He
Sep 23, 2008·Seminars in Immunology·J Rodrigo Mora, Ulrich H von Andrian

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