PMID: 2508312Jan 1, 1989Paper

Colonic pericryptal fibroblasts. Differentiation pattern in embryogenesis and phenotypic modulation in epithelial proliferative lesions

Virchows Archiv. A, Pathological Anatomy and Histopathology
A P SappinoG Gabbiani

Abstract

Experimental evidence has shown that fetal gut mesenchymal cells can modulate epithelial cell differentiation. It is postulated that reciprocal stromal-epithelial interactions in the digestive tract are maintained beyond embryonic life. The mature colonic mucosa contains pericryptal fibroblasts (PCF), a stromal cell type exhibiting smooth muscle morphological features, which are thought to regulate the growth and differentiation of adjacent epithelial cells. Using an antibody directed at alpha-smooth muscle actin, which is constantly expressed in smooth muscle cells, we performed an immuno-histochemical study on human embryonic tissues to assess PCF differentiation during development. PCF expressing alpha-smooth muscle actin were first detected around the 21st week of gestation, at the bases of the crypts; the number of differentiated PCF increased then progressively, in synchrony with epithelial proliferation, to achieve at birth the characteristic distribution found in adults. We analyzed a series of non-malignant and malignant epithelial proliferative lesions of the adult colon by the same technique. Only sparse immunoreactive PCF were observed in 10/10 pure tubular adenomas, whereas in 11/11 villous adenomas immunoreactive ...Continue Reading

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Citations

Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·B CzernobilskyG Gabbiani
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