Colonic perineurioma (benign fibroblastic polyp): case report and review of the literature

Diagnostic Pathology
Abraham Christoffel van WykJonathan Rigby

Abstract

Colorectal perineuriomas are uncommon benign mucosal-based proliferations of mesenchymal cells that express perineurial markers, often associated with colonic crypts displaying a serrated/hyperplastic architecture. The vast majority of cases arise distal to the splenic flexure and have been described as sessile polyps. Using molecular analysis, BRAF mutations have been demonstrated in the serrated crypt epithelium. We report a new case of perineurioma presenting as a pedunculated polyp in the transverse colon, with prominent hemosiderin deposits in the uninvolved lamina propria that separated the perineurial proliferation from the surface epithelium, a previously unreported histological finding. By using immunohistochemistry, we demonstrated the presence of BRAF V600E mutated protein in the serrated crypt epithelium. In addition, a review of the literature on colorectal perineurioma is provided. A 5 mm pedunculated polyp was removed from the transverse colon of a 42 year old man who presented with epigastric pain, weight loss and rectal bleeding. A proliferation of uniform plump spindled cells expanded the lamina propria and separated serrated colonic crypts. The epithelial component closely resembled microvesicular hyperplasti...Continue Reading

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Citations

Sep 29, 2018·BMJ Case Reports·Guled M JamaDeepak Singh-Ranger
May 18, 2019·Journal of Clinical Pathology·Newton A C S Wong, Orla O'Mahony
Dec 24, 2018·Clinical Medicine Insights. Pathology·Tomoyuki OtaniChiho Ohbayashi
Dec 15, 2020·American Journal of Clinical Pathology·Erika Hissong, Rhonda K Yantiss
Feb 27, 2021·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Dong Geon LeeTae Oh Kim
Jun 23, 2021·Curēus·Sara KamionkowskiAnnette Kyprianou

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Methods Mentioned

BETA
biopsies

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