Colonic transit in patients after anterior resection: prospective, comparative study using single-photon emission CT/CT scintigraphy

The British Journal of Surgery
K-S NgM A Gladman

Abstract

Bowel dysfunction after anterior resection is well documented, but its pathophysiology remains poorly understood. No study has assessed whether postoperative variation in colonic transit contributes to symptoms. This study measured colonic transit using planar scintigraphy and single-photon emission CT (SPECT)/CT in patients after anterior resection, stratified according to postoperative bowel function. Symptoms were assessed using the low anterior resection syndrome (LARS) score. Following gallium-67 ingestion, scintigraphy was performed at predefined time points. Nine regions of interest were defined, and geometric centre (GC), percentage isotope retained, GC velocity index and colonic half-clearance time (T½ ) determined. Transit parameters were compared between subgroups based on LARS score using receiver operating characteristic (ROC) curve analyses. Fifty patients (37 men; median age 72·6 (range 44·4-87·7) years) underwent planar and SPECT scintigraphy. Overall, 17 patients had major and nine had minor LARS; 24 did not have LARS. There were significant differences in transit profiles between patients with major LARs and those without LARS: GCs were greater (median 5·94 (range 2·35-7·72) versus 4·30 (2·12-6·47) at 32 h; P ...Continue Reading

References

Dec 1, 1992·International Journal of Colorectal Disease·R G McLeanN A Talley
Apr 1, 1991·Diseases of the Colon and Rectum·G BatignaniF Tonelli
Aug 1, 1986·Annals of Surgery·I K PedersenP E Mortensen
Apr 1, 1985·Nuclear Medicine Communications·J G Hardy, A C Perkins
Dec 1, 1983·The British Journal of Surgery·P J McDonald, R J Heald
Sep 1, 1980·The British Journal of Surgery·H SuzukiM Honzumi
Oct 1, 1995·The British Journal of Surgery·A S MillerP J Finan
Jan 1, 1995·International Journal of Colorectal Disease·J S VassilakisE Xynos
Oct 7, 1993·The New England Journal of Medicine·M R von der OheG M Thomforde
Jan 1, 1996·International Journal of Colorectal Disease·H Ortiz, P Armendariz
Jan 1, 1996·International Journal of Colorectal Disease·G N RaoG S Duthie
Jan 1, 1997·International Journal of Colorectal Disease·K E MatzelW Hohenberger
Dec 31, 1998·International Journal of Colorectal Disease·S J Lee, Y S Park
Dec 17, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Gregor J FörsterPeter Bartenstein
Sep 26, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S M Scott
Mar 1, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G BassottiF Pucciani
Mar 7, 2006·Seminars in Nuclear Medicine·Alan H Maurer, Henry P Parkman
Dec 13, 2006·Seminars in Nuclear Medicine·Orazio SchillaciGiovanni Simonetti
May 6, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael CamilleriAlan R Zinsmeister
Jan 15, 2010·Nuclear Medicine Communications·Kottekkattu BalanStephen Middleton
Dec 9, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S S C RaoL Szarka
Feb 2, 2012·Seminars in Nuclear Medicine·Lawrence A Szarka, Michael Camilleri
Feb 9, 2012·Advanced Drug Delivery Reviews·Joy Conway
Feb 11, 2012·Journal of Neurogastroenterology and Motility·Eun Ran Kim, Poong-Lyul Rhee
Apr 11, 2012·CA: a Cancer Journal for Clinicians·Lauren KosinskiRodrigo Perez
Sep 1, 2012·The Lancet Oncology·Catherine L C BryantChristopher L H Chan
May 14, 2014·Diseases of the Colon and Rectum·Therese JuulPeter Christensen
Jun 21, 2014·Seminars in Nuclear Medicine·Piotr J SlomkaGuido Germano
Aug 22, 2014·Current Radiopharmaceuticals·Andrea CiarmielloMaria Chiara Gaeta
Feb 24, 2015·Clinical Nuclear Medicine·Jose Rafael InfanteManuel Moreno
Nov 3, 2015·Seminars in Nuclear Medicine·Lefteris Livieratos

❮ Previous
Next ❯

Citations

Dec 1, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Celia KeaneGreg O'Grady
Feb 28, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Frank D McDermott
Apr 21, 2021·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·Sigmar StelznerSören Torge Mees
Jul 24, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rui SunYi Xiao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.