Colonic transit influences deoxycholic acid kinetics

Gastroenterology
M J VeyseyR H Dowling

Abstract

Prolonged large bowel transit, and an increase in the proportion of deoxycholic acid (DCA), have been implicated in the pathogenesis of cholesterol gallstones-including those developing in acromegalics treated with octreotide. However, there are few data on the effects of intestinal transit on bile acid kinetics. We therefore measured the kinetics of DCA and cholic acid (CA) using stable isotopes, serum sampling, and mass spectrometry. The results were related to mouth-to-caecum (MCTT) and large bowel transit times (LBTTs) in 4 groups of 8 individuals: (1) non-acromegalic controls, (2) acromegalics untreated with octreotide, (3) acromegalics on long-term octreotide, and (4) patients with constipation. Paired, before and during octreotide, studies were performed in 5 acromegalics. In the unpaired and paired studies, octreotide significantly prolonged MCTT and LBTT. In the paired studies, the octreotide-induced prolongation of LBTT caused an increase in the DCA input rate (6.4 +/- 2.8 to 12 +/- 2.6 micromol. kg. d, P < 0.05) and pool size (18 +/- 12 to 40 +/- 13 micromol/kg, P < 0.05), and a decrease in CA pool size (45 +/- 15 to 25 +/- 11 micromol/kg, P < 0.05). Furthermore, during octreotide treatment, the mean conversion of 13...Continue Reading

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Citations

Jul 23, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mariëtte Y M van der WulpHenkjan J Verkade
Mar 7, 2006·Applied and Environmental Microbiology·Máire BegleyCormac G M Gahan
Feb 11, 2004·Endocrine Reviews·Annamaria ColaoGaetano Lombardi
Mar 31, 2004·The American Journal of Clinical Nutrition·Peter H BisschopJohannes A Romijn
Jul 29, 2005·Journal of Gastroenterology and Hepatology·Paola LoriaNicola Carulli
Feb 26, 2010·Isotopes in Environmental and Health Studies·Frans StellaardFolkert Kuipers
Dec 10, 2013·Isotopes in Environmental and Health Studies·Marina J M MaurerFrans Stellaard
Feb 22, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marco BertolottiMarina Del Puppo
Jun 29, 2018·Frontiers in Physiology·Fianne L P SipsNatal A W van Riel
Oct 19, 2006·Neuroendocrinology·Paul J Jenkins
Jun 8, 2021·JHEP Reports : Innovation in Hepatology·Nikolaj W ØrntoftMichael Sørensen

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