Colonization and infection with Enterococcus faecalis in intensive care units: the role of antimicrobial agents.

Antimicrobial Agents and Chemotherapy
M J M BontenE E Stobberingh

Abstract

We studied the influences of antimicrobial agents on the colonization of the respiratory tract and infection with Enterococcus faecalis in intensive care unit (ICU) patients receiving mechanical respiration for at least 3 days. In a matched-cohort analysis, patients receiving topical antimicrobial prophylaxis (TAP) of the oropharynx and stomach with antimicrobial agents not treating E. faecalis were compared with patients not receiving TAP. Patients were matched with controls on the basis of their duration in the ICU, their use of systemic antibiotics treating and not treating E. faecalis, the administration of TAP, their APACHE II score, and surgical procedures they had undergone. In all, 276 patients were analyzed. The colonization of the oropharynx and/or trachea by E. faecalis at admission was demonstrated for 43 patients (16%). Twenty patients (9%) acquired tracheal colonization and 91 patients (40%) acquired oropharyngeal colonization with E. faecalis. In the matched-cohort analysis, 43 patients receiving TAP were matched in two controls each. TAP patients more frequently acquired tracheal colonization (15 of 43 versus 2 of 86 patients, P < 0.00001) and infections with E. faecalis (6 of 43 versus 1 of 86 patients, P < 0.0...Continue Reading

References

Jul 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W Graninger, R Ragette
Jun 11, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R C Moellering
Sep 1, 1990·The American Review of Respiratory Disease·A TorresR Rodriguez-Roisin
Jan 1, 1990·Clinical Microbiology Reviews·B E Murray
Jan 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S L Berk, A Verghese
Jan 1, 1989·Reviews of Infectious Diseases·R M GullbergJ P Phair
May 1, 1987·Annals of Internal Medicine·M J ZervosD R Schaberg
Dec 1, 1988·American Journal of Infection Control·C R Magnussen, J Cave
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Nov 1, 1982·Reviews of Infectious Diseases·R C Moellering
Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·A TorresR Rodriguez-Roisin
Nov 1, 1994·American Journal of Respiratory and Critical Care Medicine·M J BontenE E Stobberingh
Oct 1, 1993·Clinical Microbiology Reviews·T G Emori, R P Gaynes
Jan 21, 1993·The New England Journal of Medicine·M J BontenC A Gaillard

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Citations

Nov 12, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·J F CarabalonaA Friggeri
Jun 5, 2002·Biochimica Et Biophysica Acta·Sławomir Milewski
Dec 22, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·I S PetersenO B Jepsen
Oct 25, 2003·Antimicrobial Agents and Chemotherapy·Laurent DubéDenis Bugnon
Oct 29, 2010·Critical Care Research and Practice·Lenneke E M Haas, Marcus J Schultz
Aug 14, 2001·American Journal of Respiratory and Critical Care Medicine·D C BergmansE E Stobberingh
Mar 17, 2010·Intensive Care Medicine·Robin F BenusTjip S van der Werf
May 22, 2010·Medicina intensiva·E Palencia Herrejón, P Rico Cepeda
Jul 28, 2009·Enfermedades infecciosas y microbiología clínica·Blanca García-San VicenteEsther Corral
Mar 31, 2009·Biochimica Et Biophysica Acta·Amit PriyadarshiKwang Yeon Hwang
Feb 24, 2001·The Medical Clinics of North America·B A Cunha
Sep 29, 2004·Uirusu·Masanori Baba
Aug 15, 1997·Medizinische Klinik·C WallrauchI Braveny
Mar 21, 1998·American Journal of Infection Control·S LloydT Lundstrom

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