Colonization of the tsetse fly midgut with commensal Kosakonia cowanii Zambiae inhibits trypanosome infection establishment.

PLoS Pathogens
Brian L WeissSerap Aksoy

Abstract

Tsetse flies (Glossina spp.) vector pathogenic trypanosomes (Trypanosoma spp.) in sub-Saharan Africa. These parasites cause human and animal African trypanosomiases, which are debilitating diseases that inflict an enormous socio-economic burden on inhabitants of endemic regions. Current disease control strategies rely primarily on treating infected animals and reducing tsetse population densities. However, relevant programs are costly, labor intensive and difficult to sustain. As such, novel strategies aimed at reducing tsetse vector competence require development. Herein we investigated whether Kosakonia cowanii Zambiae (Kco_Z), which confers Anopheles gambiae with resistance to Plasmodium, is able to colonize tsetse and induce a trypanosome refractory phenotype in the fly. Kco_Z established stable infections in tsetse's gut and exhibited no adverse effect on the fly's survival. Flies with established Kco_Z infections in their gut were significantly more refractory to infection with two distinct trypanosome species (T. congolense, 6% infection; T. brucei, 32% infection) than were age-matched flies that did not house the exogenous bacterium (T. congolense, 36% infected; T. brucei, 70% infected). Additionally, 52% of Kco_Z colon...Continue Reading

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Citations

Sep 24, 2019·Natural Product Reports·Raúl G Saraiva, George Dimopoulos
Mar 17, 2019·Nature Reviews. Microbiology·Andrea du Toit
Mar 21, 2020·Scientific Reports·Alex GaithumaChihiro Sugimoto
Oct 4, 2020·Applied and Environmental Microbiology·Tobin J HammerNoah Fierer
Jan 30, 2021·The Journal of Experimental Biology·Konstantin Schmidt, Philipp Engel

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Datasets Mentioned

BETA
CP022690.1

Methods Mentioned

BETA
irradiating
dissecting

Software Mentioned

GraphPad Prism
R
multcomp
macOS

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