DOI: 10.1101/472373Nov 16, 2018Paper

Colonization of the tsetse fly midgut with commensal Enterobacter inhibits trypanosome infection establishment

BioRxiv : the Preprint Server for Biology
Brian L WeissSerap Aksoy

Abstract

Tsetse flies (Glossina spp.) vector pathogenic trypanosomes (Trypanosoma spp.) in sub-Saharan Africa. These parasites cause human and animal African trypanosomiases, which are debilitating diseases that inflict an enormous socio-economic burden on inhabitants of endemic regions. Current disease control strategies rely primarily on treating infected animals and reducing tsetse population densities. However, relevant programs are costly, labor intensive and difficult to sustain. As such, novel strategies aimed at reducing tsetse vector competence require development. Herein we investigated whether an Enterobacter bacterium (Esp\_Z), which confers Anopheles gambiae with resistance to Plasmodium, is able to colonize tsetse and induce a trypanosome refractory phenotype in the fly. Esp\_Z established stable infections in tsetse’s gut, and exhibited no adverse effect on the survival of individuals from either group. Flies with established Esp\_Z infections in their gut were significantly more refractory to infection with two distinct trypanosome species (T. congolense, 6% infection; T. brucei, 32% infection) than were age-matched flies that did not house the exogenous bacterium (T. congolense, 36% infected; T. brucei, 70% infected). A...Continue Reading

Related Concepts

Enterobacter
Extrasensory Perception
Parasites
Serratia marcescens
Trypanosoma
Trypanosoma brucei brucei
Trypanosoma congolense
Glossina
Primitive Midgut Structure
Anopheles gambiae

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