PMID: 6966350Jan 1, 1980Paper

Colony stimulating activity in sera of erythroleukemic mice (RLV-A)

Journal of Surgical Oncology
L KoltunT N Fredrickson

Abstract

RLV-A serum activity was measured by the agar colony assay to determine the effect of this erythroid dyscrasia on the granulopoietic humoral regulator, colony stimulating factor (CSF). In general, the sera of early, midstage and terminal animals not given endotoxin had high cluster forming properties compared to normal sera. The sera of early, midstage, and terminal mice treated with endotoxin had only a fraction of the colony forming ability of serum obtained from normal endotoxin-treated mice (EMS) with the earliest stages of the disease showing least activity followed by a rise in activity paralleling normal EMS, as the disease progressed. Sera from RLV-A endotoxin treated mice retained ability to stimulate cluster growth especially when compared to the slight activity displayed by normal endotoxin treated mouse sera.

References

Jun 1, 1966·The Australian Journal of Experimental Biology and Medical Science·T R Bradley, D Metcalf
Dec 1, 1968·The Australian Journal of Experimental Biology and Medical Science·E R StanleyG L Ada
Oct 1, 1966·Experimental Cell Research·D H Pluznik, L Sachs

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Citations

Dec 15, 2015·Journal of Basic and Clinical Physiology and Pharmacology·Jagan NadipellyViswanathan Subramanian

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