Colony-stimulating factor 1 and its receptor are new potential therapeutic targets for allergic asthma.

Allergy
Hyung-Geun MoonGye Young Park

Abstract

A new approach targeting aeroallergen sensing in the early events of mucosal immunity could have greater benefit. The CSF1-CSF1R pathway has a critical role in trafficking allergens to regional lymph nodes through activating dendritic cells. Intervention in this pathway could prevent allergen sensitization and subsequent Th2 allergic inflammation. To examine the therapeutic effectiveness of CSF1 and CSF1R inhibition for blocking the dendritic cell function of sensing aeroallergens. We adopted a model of chronic asthma induced by a panel of three naturally occurring allergens and novel delivery system of CSF1R inhibitor encapsulated nanoprobe. Selective depletion of CSF1 in airway epithelial cells abolished the production of allergen-reactive IgE, resulting in prevention of new asthma development as well as reversal of established allergic lung inflammation. CDPL-GW nanoprobe containing GW2580, a selective CSF1R inhibitor, showed favorable pharmacokinetics for inhalational treatment and intranasal insufflation delivery of CDPL-GW nanoprobe ameliorated asthma pathologies including allergen-specific serum IgE production, allergic lung and airway inflammation and airway hyper-responsiveness (AHR) with minimal pulmonary adverse reac...Continue Reading

References

May 12, 2000·American Journal of Respiratory and Critical Care Medicine·S ZhuA J Sandford
Jan 16, 2002·American Journal of Respiratory and Critical Care Medicine·Helen L RhodesJeremy J Cogswell
Jan 6, 2009·Immunological Reviews·Olivier JoffreCaetano Reis e Sousa
Sep 22, 2009·Immunity·Bart N Lambrecht, Hamida Hammad
Nov 9, 2010·Nature Biotechnology·Hak Soo ChoiAkira Tsuda
Mar 18, 2011·The New England Journal of Medicine·William W BusseChristine A Sorkness
Sep 21, 2013·American Journal of Respiratory and Critical Care Medicine·Gye Young ParkJohn W Christman
Jun 4, 2014·Cold Spring Harbor Perspectives in Biology·E Richard Stanley, Violeta Chitu
Aug 31, 2014·The Journal of Allergy and Clinical Immunology·Bart N Lambrecht, Hamida Hammad
Sep 17, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zbigniew ZasłonaMarc Peters-Golden
Dec 19, 2014·Nature Immunology·Jeffrey A Whitsett, Theresa Alenghat
Feb 24, 2015·The New England Journal of Medicine·George Du ToitUNKNOWN LEAP Study Team
Apr 29, 2015·The Journal of Allergy and Clinical Immunology·Joanne E SordilloAugusto A Litonjua
Jul 23, 2015·Immunity·Hamida Hammad, Bart N Lambrecht
Jul 30, 2015·The New England Journal of Medicine·William D TapGideon Bollag
Nov 1, 2015·The Journal of Allergy and Clinical Immunology·Stephen J TeachStanley J Szefler
Jan 10, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandra BajañaSusan Kovats
Jan 18, 2016·The Journal of Allergy and Clinical Immunology·Steve TurnerUNKNOWN Pharmacogenomics in Childhood Asthma Consortium
Jul 15, 2016·Advanced Materials·Homan KangHak Soo Choi
Oct 25, 2016·The Journal of Allergy and Clinical Immunology·Alexander J HoseUNKNOWN PASTURE study groups
May 4, 2017·Nature Reviews. Immunology·Martin Guilliams, Charlotte L Scott
Oct 1, 2017·Cold Spring Harbor Perspectives in Biology·David A AndersonCarlos G Briseño

❮ Previous
Next ❯

Citations

May 28, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Mary Kathryn BohnKhosrow Adeli
May 10, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Ivana LapićMario Plebani
Oct 1, 2020·Allergy·Lacin CevhertasCezmi A Akdis
Mar 13, 2021·Cell·Hamida Hammad, Bart N Lambrecht
Jul 25, 2021·Cellular & Molecular Immunology·Juan LiuXuetao Cao
Aug 16, 2021·Allergy·Ioana AgacheMarek Jutel
Sep 4, 2021·Journal of Medicinal Chemistry·Zhicheng XieYouhong Hu
Sep 15, 2021·Allergy·Ismail OgulurCezmi A Akdis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.