Colony-stimulating factor 1-dependent resident macrophages play a regulatory role in fighting Escherichia coli fecal peritonitis.

Infection and Immunity
W Wiktor-JedrzejczakP Szwech

Abstract

Osteopetrotic op/op mice have less than 5% of the normal number of macrophages in the peritoneal cavity (W. Wiktor-Jedrzejczak, A. Ahmed, C. Szczylik, and R.R. Skelly, J. Exp. Med. 156:1516-1527, 1982). Fecal peritonitis was induced by intraperitoneal injection of 0.5 ml of 5% autoclaved feces in saline along with Escherichia coli grown from feces of mice of the same colony and added in doses ranging between 10 and 10(6) CFU. Such infection led to a septic shock and either was lethal within 24 h or became cured without additional treatment of the mice. The op/op mice survived administration of 30-times-smaller doses of bacteria compared with their normal littermates. Analysis of the kinetics of cellular changes in the peritoneal cavity associated with such infection revealed that this increased susceptibility of macrophage-deficient mice cannot be explained by a direct role of macrophages in combating the infection. Instead, it appeared that the increased susceptibility to fatal fecal peritonitis was most likely due to delayed and impaired recruitment of neutrophils to the site of infection in mutant mice. The increased susceptibility of the op/op mice to E. coli fecal peritonitis was not due to their possible increased sensiti...Continue Reading

References

Jan 1, 1992·Annual Review of Immunology·P Vassalli
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W Wiktor-JedrzejczakE R Stanley
Jul 1, 1989·The Journal of Infectious Diseases·A G MatlowJ Meakins
Sep 1, 1989·Endocrinology·B F BoyceG R Mundy
Jul 1, 1993·Infection and Immunity·A S CrossP Gemski

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Citations

Apr 26, 2003·Journal of Leukocyte Biology·Frank SchönlauJan Ehrehen
Apr 25, 2008·The Journal of Pharmacology and Experimental Therapeutics·James G ConwayThomas A Brodie
Jan 18, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daisuke KurotakiJunko Morimoto
Oct 17, 2014·Immunological Reviews·Charlotte L ScottMartin Guilliams

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