Colony-stimulating factor-1 in immunity and inflammation

Current Opinion in Immunology
Violeta Chitu, E Richard Stanley

Abstract

Colony-stimulating factor-1 (CSF-1, also known as macrophage-CSF) is the primary regulator of the survival, proliferation, differentiation and function of mononuclear phagocytes. Studies that involve CSF-1-deficient mice demonstrate that there is a variable requirement for CSF-1 in the development of individual mononuclear phagocyte populations. However, these cells uniformly express the CSF-1 receptor, and their morphology, phagocytosis and responsiveness to infectious and non-infectious stimuli is regulated by CSF-1. CSF-1 plays important roles in innate immunity, cancer and inflammatory diseases, including systemic lupus erythematosus, arthritis, atherosclerosis and obesity. In several conditions, activation of macrophages involves a CSF-1 autocrine loop. In addition, secreted and cell-surface isoforms of CSF-1 can have differential effects in inflammation and immunity.

References

Aug 1, 1994·The Journal of Experimental Medicine·W J de VilliersS Gordon
Jan 1, 1996·Clinical and Experimental Immunology·G VanhamJ J Ellner
Jan 1, 1997·Molecular Reproduction and Development·B M Kacinski
May 16, 1998·The Journal of Clinical Investigation·J A LevineT O'Brien
Apr 29, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·W J de VilliersS Gordon
Jun 19, 1998·International Journal of Hematology·K Motoyoshi
Jun 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Nemunaitis
Jun 24, 1998·The Journal of Clinical Investigation·T RajavashisthA Lusis
Oct 3, 1999·European Journal of Immunology·S P RobinsonC D Reid
Aug 10, 2000·Neuropathology : Official Journal of the Japanese Society of Neuropathology·A SasakiY Nakazato
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·W ZouT J Curiel
Mar 10, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·C C WilliamsM R Jadus
Mar 21, 2001·The Journal of Experimental Medicine·E Y LinJ W Pollard
Aug 2, 2001·Journal of Biochemistry·K Nakajima, S Kohsaka
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew J SweetFoo Y Liew
Apr 18, 2002·Neurobiology of Aging·Valerie A M VincentGreer M Murphy
May 11, 2002·The Journal of Bone and Joint Surgery. British Volume·T T YangN A Athanasou
Jul 26, 2002·International Journal of Hematology·Kiyoko S Akagawa
Sep 14, 2002·Annals of the Rheumatic Diseases·L DanksN A Athanasou
Oct 16, 2002·Glia·Yoshinori Imai, Shinichi Kohsaka
Oct 18, 2002·Arthritis and Rheumatism·Norikuni KawanakaHirofumi Makino
Mar 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Matthew D JoseSteven J Chadban
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deborah M LendaVicki R Kelley
Mar 12, 2003·Journal of Leukocyte Biology·Andrea la SalaGiampiero Girolomoni
Apr 16, 2003·Xenotransplantation·Yong ZhaoAlan N Langnas
Jun 18, 2003·The Journal of Experimental Medicine·Petronela AncutaDana Gabuzda
Jun 19, 2003·Neuroscience Letters·Olivera M MitrasinovicGreer M Murphy

❮ Previous
Next ❯

Citations

May 10, 2013·Seminars in Immunopathology·Subhra K BiswasAlberto Mantovani
May 4, 2010·Histochemistry and Cell Biology·Ssu-Yi LuYi-Ling Lin
May 19, 2011·Genes & Nutrition·Betul Catalgol, Nesrin Kartal Ozer
Jul 23, 2013·Fish & Shellfish Immunology·Dimitar B IlievJorunn B Jørgensen
Jul 6, 2011·Immunology and Cell Biology·Jason C LenzoJohn A Hamilton
Sep 24, 2013·Nature Medicine·Stephanie M PyonteckJohanna A Joyce
Oct 19, 2012·Nature Reviews. Cancer·Kenneth Verstraete, Savvas N Savvides
Jun 14, 2008·Nature Reviews. Immunology·John A Hamilton
Mar 14, 2009·Nature Reviews. Immunology·Jeffrey W Pollard
Dec 18, 2013·The New England Journal of Medicine·Brian W Parks, Aldons J Lusis
Nov 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyan ChenXiaolin He
Mar 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Chao ZhangGideon Bollag
Jan 9, 2013·The Journal of Experimental Medicine·Jian LuoTony Wyss-Coray
Oct 9, 2013·The Journal of Experimental Medicine·Stephen J JenkinsJudith E Allen
Jun 30, 2007·Antioxidants & Redox Signaling·Gerd Schmitz, Margot Grandl
May 20, 2008·Cardiovascular Research·Robert KleemannTeake Kooistra
Nov 1, 2011·Annals of the Rheumatic Diseases·M ChemelD Heymann
Mar 24, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Amanda M GuthSteven W Dow
Apr 17, 2012·International Journal of Cell Biology·Fiona J Pixley
Oct 13, 2007·The Journal of Clinical Investigation·Sijin LiuJane-Jane Chen
Nov 27, 2008·The Journal of Clinical Investigation·Jeffrey W Pollard
Jul 10, 2009·The Journal of Clinical Investigation·Julia MenkeVicki R Kelley
Oct 6, 2007·Blood·Ben FanckeMeredith O'Keeffe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.