Color Doppler sonographic detection of tumor flow in superficial melanoma metastases: histologic correlation

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
A A AlexanderM J Mastrangelo

Abstract

Color Doppler sonographic detection of tumor flow within superficial melanoma metastases was investigated to determine if tumor size, vessel size, or vessel number influences signal detection. Color Doppler imaging of 32 pathologically proved melanoma metastases was performed at 6 MHz with color Doppler imaging parameters optimized for each lesion scanned. All lesions were measured in three dimensions and the presence or absence of internal flow was documented. Seven surgically excised metastases underwent immunohistochemical staining for endothelial markers. Internal flow was detected in 21 of 32 masses and was completely absent in 11. In comparison to all masses without flow, the masses with flow had significantly greater anteroposterior dimensions (P < 0.00036) and volumes (P < 0.01). Histologically, mean vessel diameter in masses with flow was significantly greater (P < 0.05) than in those without flow, but mean vessel number was not significantly different. In conclusion, detectability of tumor blood flow in superficial melanoma metastasis may be related more to tumor size and vessel size than vessel number. Failure to detect color signal within a superficial melanoma mass does not indicate a lack of internal vascularity.

Citations

Jan 20, 2006·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Markus StückerPeter Altmeyer
Jul 29, 2011·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Orlando CatalanoAdolfo Gallipoli D'Errico
Jan 8, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Sun Jae WonYoung Jin Ko
Jan 23, 2003·Microscopy Research and Technique·Anurag SrivastavaJatinder Kaur
May 23, 2014·AJR. American Journal of Roentgenology·Bradley J CarraDillon C Chen
Jun 11, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Rick FeldPaul G Curcillo
Dec 8, 2007·Expert Review of Anticancer Therapy·Gregor Schäfer-HesterbergChristiane Voit
Nov 11, 2003·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Francesco GiovagnorioAmalia Paonessa

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