Color Fundus Photography, Optical Coherence Tomography, and Fluorescein Angiography in Diagnosing Polypoidal Choroidal Vasculopathy

American Journal of Ophthalmology
Voraporn ChaikitmongkolNeil M Bressler

Abstract

To determine sensitivity and specificity of polypoidal choroidal vasculopathy (PCV) diagnosis using color fundus photography (CFP), optical coherence tomography (OCT), and fundus fluorescein angiography (FFA) without indocyanine green angiography (ICGA). Validity analysis. Treatment-naïve eyes with serous/serosanguinous maculopathy undergoing CFP, OCT, FFA, and ICGA imaging before treatment at a university hospital in Thailand (January 1, 2013 to June 30, 2015) were identified. Images of each subject were categorized into 4 sets (set A: CFP; set B: CFP+OCT; set C: CFP+FFA; set D: CFP+OCT+FFA). Six graders, 3 from Thailand (PCV endemic area) and 3 from the United States (nonendemic area), individually reviewed each set (without ICGA), and determined if the presumed diagnosis was PCV. In parallel, 2 other graders confirmed if each case had PCV or not using EVEREST criteria (including ICGA). Sensitivity and specificity of a PCV diagnosis with each set (without ICGA) were analyzed compared with diagnoses including ICGA. Of 119 study eyes (113 subjects, 57% male, mean age ± SD 59.9 ± 13.8 years), definite PCV diagnosis was 40.3%. Sensitivity of sets A, B, C, D: 0.63 (95% confidence interval [CI]: 0.47-0.76), 0.83 (95% CI: 0.69-0.92)...Continue Reading

Citations

Apr 26, 2020·Asia-Pacific Journal of Ophthalmology·Voraporn ChaikitmongkolTimothy Y Y Lai
Aug 26, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Zongyi ZhanXiaoyan Ding
Apr 24, 2020·Eye and Vision·Yan TongYin Shen
May 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yue ZhaoXiaofei An
Feb 14, 2020·Journal of Ophthalmology·Nelly N KabediJean-Claude Mwanza
Nov 18, 2019·BMC Ophthalmology·Jingyuan YangYouxin Chen

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