Color Reflectivity Discretization Analysis of OCT Images in the Detection of Glaucomatous Nerve Fiber Layer Defects

Journal of Glaucoma
Sonya B ShahJonathan S Myers

Abstract

To compare the ability of Cirrus retinal nerve fiber layer (RNFL) thickness and the Color Reflectivity Discretization Analysis (CORDA), a novel optical coherence tomography (OCT) analysis method, to differentiate between normal subjects, glaucoma suspects, and glaucoma patients. Analysis of peripapillary OCT images using Cirrus SD-OCT (optic nerve head cube 200 × 200 protocol) and postacquisition CORDA analysis of peripapillary RNFL B-scan images was performed. In total, 291 eyes of 148 subjects (94 normal eyes, 100 primary open-angle glaucoma suspect eyes, and 97 eyes with primary open-angle glaucoma) were included. Area under the receiver operating characteristic curve was estimated for each region and method (Cirrus vs. CORDA) for differentiating eyes with glaucoma, and those that are glaucoma suspect, from normal eyes. CORDA HR1 parameter discriminated glaucoma patients from normal subjects more accurately than Cirrus RNFL thickness in nasal (P = 0.003) and temporal (P = 0.001) regions. HR1 showed greater area under the receiver operating characteristic curve than Cirrus RNFL thickness when discriminating glaucoma suspects from normal subjects in the superior (P = 0.02), nasal (P = 0.003), and temporal (P = 0.001) regions. ...Continue Reading

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Methods Mentioned

BETA
light scattering

Software Mentioned

Cirrus
CORDA
SAS
Stata

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