Coloration phenomenon of mefenamic acid in mesoporous silica FSM-16

Chemical & Pharmaceutical Bulletin
Kunikazu MoribeKeiji Yamamoto

Abstract

Coloration of mefenamic acid (MFA) was investigated in the presence of mesoporous silica FSM-16 with 16.0 A (Oc) and 45.0 A (Doc) pore diameter. The color change of MFA/FSM-16 physical mixture from white to deep blue was observed by sealed-heating (SH) and the subsequent humidification (HU). The coloration and the color difference were caused by the changes of chroma and lightness. In the case of MFA/FSM-16 (Oc), coloration was not observed by SH treatment only. Powder X-ray diffraction data indicated that difference of the dispersed states of MFA molecules in FSM-16 mesopore affected the coloration. MFA adsorbed on the silica surface and MFA in the mesopore were differentiated by thermogravimetric analysis. Solid-state (13)C-NMR showed that the molecular mobility of MFA was increased in the dispersed state in FSM-16 mesopores compared to the crystalline state. Structural changes of silanol groups in FSM-16 by humidification were observed by solid-state (29)Si-NMR. MFA adsorption in FSM-16 mesopore by SH as well as changes of the surface state of FSM-16 by HU affected the coloration of MFA.

References

Feb 15, 2003·Journal of Pharmaceutical Sciences·Patrick A TishmackStephen R Byrn
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Jun 15, 2005·Journal of Colloid and Interface Science·Yuichi TozukaKeiji Yamamoto
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Sep 14, 2006·Pharmaceutical Research·Adchara PongpeerapatKeiji Yamamoto
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Citations

Feb 8, 2011·Chemical & Pharmaceutical Bulletin·Keiji YamamotoKunikazu Moribe
Mar 27, 2012·International Journal of Pharmaceutics·Shuichi TanabeKunikazu Moribe

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