Colorectal adenocarcinoma in Crohn's disease

Annals of Surgery
M B RibeiroA H Aufses

Abstract

The authors' aim was to review the clinical features and estimate the long-term survival of patients with colorectal carcinoma complicating Crohn's disease. Recent studies have demonstrated a significantly increased risk of colorectal carcinoma in patients with Crohns disease. The authors reviewed retrospectively the medical records of 30 patients with Crohn's disease admitted to The Mount Sinai Hospital between 1960 and 1989 in whom colorectal adenocarcinoma developed. All patients were operated on and follow-up was complete for all patients to 10 years after operation, to the time of death, or to the closing date of the study in December 1989. The 30 patients in the series had 33 colorectal adenocarcinomas; three patients (10%) presented with two synchronous cancers. The patients were relatively young (mean age, 53 years) and had long-standing Crohn's disease (duration >20 years in 87%). The 5-year actuarial survival was 44% for the overall series: 100% for stage A, 86% for stage B, 60% for stage C. All five patients with excluded bowel tumor died of large bowel cancer within 2.4 years; by contrast, the actuarial 5-year survival for patients with in-continuity tumors was 56%. The incidence, characteristics, and prognosis of c...Continue Reading

References

Jan 1, 1977·British Journal of Haematology·J Palek
May 1, 1976·The British Journal of Surgery·M Whittaker, J C Goligher
Jan 1, 1990·Diseases of the Colon and Rectum·P E SavocaC E Cahow
Jan 1, 1985·Gastroenterology·G M AndersonD J Cohen
Apr 1, 1989·Scandinavian Journal of Gastroenterology·Z FiremanT Gilat
Aug 1, 1985·Gastroenterology·S R Hamilton
Oct 1, 1986·Cancer·S H Mir-MadjlessiG J Beck
Jan 1, 1986·Scandinavian Journal of Gastroenterology·N KvistS Jarnum
Mar 1, 1973·The British Journal of Surgery·S G DarkeD J Pollock
Nov 22, 1973·The New England Journal of Medicine·D D WeedonW F Taylor
Jul 20, 1972·The New England Journal of Medicine·B I KorelitzH D Janowitz
Dec 1, 1965·The British Journal of Surgery·J D AtwellJ C Goligher
Dec 1, 1965·Proceedings of the Royal Society of Medicine·P S Boulter
Aug 1, 1967·Gut·J E Lennard-Jones, G A Stalder
Sep 1, 1980·American Journal of Surgery·P BuchmannJ Alexander-Williams
Dec 1, 1984·Journal of Clinical Gastroenterology·B T Cooper
Mar 1, 1983·Histopathology·J R Jass
May 1, 1983·Histopathology·E M ThompsonA B Price
Sep 1, 1981·Gut·J K RitchieJ E Lennard-Jones
Dec 15, 1981·Cancer·A J GreensteinA H Aufses
Apr 1, 1980·Diseases of the Colon and Rectum·J A van Heerden, R W Beart
Jul 15, 1980·Cancer·A J GreensteinA H Aufses
Dec 1, 1980·Gut·S N GydeR N Allan
Dec 1, 1994·Gastroenterology·P G PerssonG Hellers
Dec 1, 1993·Gastroenterology·P MunkholmV Binder
Oct 31, 1959·Lancet·G SLANEY, B N BROOKE
Oct 10, 1959·British Medical Journal·D WHEATLEY
Sep 1, 1961·Gut·J S CORNES, M STECHER

❮ Previous
Next ❯

Citations

Jan 30, 2009·Inflammatory Bowel Diseases·Bernardino C BrancoAdrian J Greenstein
Sep 6, 2001·Diseases of the Colon and Rectum·H KotanagiK Koyama
Aug 11, 2012·Abdominal Imaging·Lora HristovaValérie Laurent
Jul 19, 2006·International Journal of Colorectal Disease·Sabine KerstingChristian F Krieglstein
Dec 7, 2007·Techniques in Coloproctology·P J MitchellN Y Haboubi
Mar 24, 2005·Diseases of the Colon and Rectum·Alessandro FicheraFabrizio Michelassi
May 27, 2006·Diseases of the Colon and Rectum·Justin A MaykelRobert D Madoff
Jul 18, 2006·Diseases of the Colon and Rectum·Bohuslav MelicharKarel Dedic
Jun 15, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Alessandro Fichera, Fabrizio Michelassi
Mar 12, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Bernhard W RenzAxel Kleespies
Nov 26, 1999·Journal of Gastroenterology and Hepatology·N Barwood, C Platell
Dec 14, 2002·Inflammatory Bowel Diseases·Charles N BernsteinPhilip H Gordon
Aug 7, 2003·Inflammatory Bowel Diseases·Sonia FriedmanFrancis A Farraye
Aug 30, 2008·Journal of Gastroenterology and Hepatology·Yutaka YanoAkinori Iwashita
Feb 27, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M OuaïssiY Panis
Apr 4, 2014·World Journal of Gastroenterology : WJG·Aude BressenotLaurent Peyrin-Biroulet
Jan 5, 2002·International Journal of Colorectal Disease·G AlmogyA Eid
Dec 5, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Rakesh SinhaScott Sanders
Jul 23, 2004·The Journal of Small Animal Practice·M CravenM L Chandler
Mar 31, 2016·International Journal of Colorectal Disease·Jochen K LennerzGregory Y Lauwers
Dec 10, 2008·Annals of Epidemiology·David SchottenfeldFawn D Vigneau
Jan 3, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gianluca M SampietroDiego Foschi
Jun 28, 2011·AJR. American Journal of Roentgenology·Rakesh SinhaArumugam Rajesh
Nov 6, 2004·The Medical Clinics of North America·Sapna SyngalC Richard Boland
Oct 14, 2006·The American Journal of Gastroenterology·Mette LarsenHenrik T Sørensen
Jan 19, 2018·Mucosal Immunology·H JiangZ Ran
Aug 14, 2008·World Journal of Gastroenterology : WJG·Vikram B ReddyWalter E Longo
Nov 12, 2016·World Journal of Gastroenterology : WJG·James Wt TohChristopher J Young
May 2, 2000·Diseases of the Colon and Rectum·E CirincioneJ J Bauer
Sep 29, 2019·Journal of the Anus, Rectum and Colon·Yukiko HiranoTakafumi Maekawa
Mar 16, 2013·Journal of Gastroenterology and Hepatology·Yutaka YanoKitaro Futami
May 1, 1999·Diseases of the Colon and Rectum·R MayerR D Madoff
Nov 21, 2020·Diseases of the Colon and Rectum·Ahmad AlsughayerAmy L Lightner
Jul 4, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniela HirschTimo Gaiser
Dec 20, 2011·Gastroenterology·Susan GalandiukTrevor A Graham
Jun 9, 2010·Archives of Pathology & Laboratory Medicine·Noam Harpaz, Alexandros D Polydorides
Jun 29, 2021·Surgical Case Reports·Kazuhide IshimaruTakeshi Nagayasu
Mar 4, 1999·Primary Care·M O Brown
Nov 4, 2004·Gastroentérologie Clinique Et Biologique·Axèle ChampaultYves Panis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

World Journal of Gastroenterology : WJG
Jonas Mudter
Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
R I SjödahlJ D Söderholm
© 2021 Meta ULC. All rights reserved