Colorectal cancer after negative colonoscopy in fecal immunochemical test-positive participants from a colorectal cancer screening program

Endoscopy International Open
Liseth Rivero-SánchezPROCOLON group

Abstract

Background and study aims  Colorectal cancer (CRC) risk after a positive fecal immunochemical test (FIT) and negative colonoscopy is unknown. We aimed to ascertain the cumulative incidence of post-colonoscopy colorectal cancer (PCCRC) and the manifestation of other lesions that could explain the test positivity in individuals with a negative colonoscopy in a population screening program. Patients and method  Observational study in participants from the first round of a CRC screening program (2010 - 2012) with positive-FIT (≥ 20 μg/g of feces) and negative colonoscopy (without neoplasia). A 42- to 76-month follow-up was performed searching in the National Health Service database and by a brief structured telephonic interview. Results  Of 2659 FIT-positive individuals who underwent colonoscopy, 811 (30.5 %) had a negative colonoscopy. Three PCCRC (0.4 %) were detected within 11 - 28 months and accelerated carcinogenesis was ruled out. Among those with normal colonoscopy, 32 (5 %) relevant lesions were detected at follow-up. One-third of them (11/32) were significant neoplasias: a gastric cancer, a small-bowel lymphoma, six advanced colorectal adenomas, and the three PCCRC. The 21 remaining lesions were inflammatory, vascular diso...Continue Reading

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Jan 15, 2020·World Journal of Gastroenterology : WJG·Noel Pin-Vieito On Behalf Of The Colonpredict Study Investigators
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Dec 2, 2021·Gastroenterología y hepatología·Gemma Ibáñez-SanzUNKNOWN PhD on behalf of the MSIC-SC research group

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Methods Mentioned

BETA
lavage
sedation

Software Mentioned

SPSS Statistics

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