Colorectal cancer: pharmacogenetics support for the correct drug prescription

Pharmacogenomics
Gladys OliveraSalvador F Aliño

Abstract

Pharmacogenetics (PGx) in clinical practice is a tool that the clinician can use to guide, in a personalized way, the most suitable treatment that will be administered to the patient. The objective of this review is to summarize in a practical and accessible rational way, the advances that currently exist for the application of PGx in colorectal cancer chemotherapy management through the study of the patients' germline polymorphisms. To define the polymorphisms that can be applied, we rely on three fundamental cornerstones: the recommendations of drug regulatory agencies; the implementation guidelines prepared by expert consortia in PGx and information from clinical annotations (the drug/polymorphism relation) according to the scientific level of evidence assigned by PharmGKB experts.

References

Apr 15, 1994·Cancer·J F KerrB V Harmon
Apr 20, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·André B P van Kuilenburg
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tyvin A RichStephen T Mosley
Feb 7, 2008·Clinical Pharmacology and Therapeutics·J J SwenV H M Deneer
Jan 14, 2009·Molecular Cancer Therapeutics·Sarah R McWhinneyHoward L McLeod
Mar 26, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Zhe-Yi HuYuan-Sheng Zhao
Apr 27, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jan PanderHenk-Jan Guchelaar
Jul 20, 2010·Cancer Epidemiology·Luis Alberto Henríquez-HernándezLeandro Fernández-Pérez
Jul 22, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A TsunodaM Kusano
Oct 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Axel Grothey
Oct 28, 2010·JAMA : the Journal of the American Medical Association·Wendy De RoockSabine Tejpar
Jan 29, 2011·Clinical Pharmacology and Therapeutics·M V Relling, T E Klein
Mar 18, 2011·Clinical Pharmacology and Therapeutics·J J SwenH-J Guchelaar
Jun 16, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Siwen Hu-LieskovanHeinz-Josef Lenz
Sep 17, 2011·Pharmacogenomics·Ursula AmstutzCarlo R Largiadèr
Sep 21, 2012·Clinical Pharmacology and Therapeutics·M Whirl-CarrilloT E Klein
Mar 5, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dan RosmarinIan Tomlinson
Jul 25, 2014·European Journal of Pharmacology·Shaloam Dasari, Paul Bernard Tchounwou
Nov 9, 2014·Journal of the National Cancer Institute·Adam M LeeRobert B Diasio
Feb 19, 2015·Oncotarget·Xandra García-GonzálezLuis A López-Fernández
Mar 31, 2015·Fundamental & Clinical Pharmacology·Marie-Christine Etienne-GrimaldiUNKNOWN French Réseau National de Pharmacogénétique Hospitalière (RNPGx)
Jul 15, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F SclafaniN Valeri
Mar 2, 2016·Pharmacogenetics and Genomics·Hanneke I VosDunja Maroeska W M te Loo
Mar 10, 2016·Therapeutic Drug Monitoring·Jong W LeeUNKNOWN CPNDS Clinical Recommendations Group
Jan 1, 2015·Nature Reviews. Disease Primers·Ernst J KuipersToshiaki Watanabe
Jul 22, 2016·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kelly E CaudleJames M Hoffman

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Methods Mentioned

BETA
biopsy
genotyping

Software Mentioned

PGx
Ensembl
SAS

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