Colorectal cancer: response to sunitinib in a heavily pretreated colorectal cancer patient

Anti-cancer Drugs
Joan Manel Gasent Blesa, Enrique Grande Pulido

Abstract

A 64-year-old man was admitted to the emergency room in May 2000 due to pelvic pain, functional disability of the lower limb, and bleeding from a rectal fistula. The patient was diagnosed with a rectum-sigma adenocarcinoma (pT1N0M0 stage). After surgery by left hemicolectomy, the patient received adjuvant chemotherapy with tegafur for 6 months. Due to the development of subsequent recurrences (infravesical relapse, bone and lung progression) associated with CEA progression and pain worsening, the patient received treatment by every available agent for the metastatic colorectal cancer, including oxaliplatin and radiotherapy; irinotecan; FOLFOX schema; oral capecitabine; raltitrexed; irinotecan and cetuximab; cetuximab as a single agent; always in combination with zolendronic acid-based treatment for pain control. Once the patient had progressed to all the approved drugs available in the market, sunitinib (50mg/day given for 4 weeks followed by 2 weeks of rest) was proposed as compassionate use. The patient received sunitinib for a total of 6 months (four cycles). On account of the nonmeasurable disease nature of the metastatic presentation in the present case, the clinical benefit was measured in terms of reduction of painkiller...Continue Reading

References

Jan 1, 1997·Diseases of the Colon and Rectum·D I Obrand, P H Gordon
Dec 24, 2003·The Cancer Journal·Diane D Davey
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pasquina MarzolaFrancesco Osculati
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Feb 9, 2007·Journal of Clinical Pharmacy and Therapeutics·I Krämer, H-P Lipp
May 5, 2007·Expert Opinion on Biological Therapy·Jeffrey C CilleyMary F Mulcahy
May 22, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M J DuffyO Topolcan
Nov 21, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J G Christensen
Oct 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard B SaltzHeinz J Lenz
Apr 3, 2008·Nature Clinical Practice. Gastroenterology & Hepatology·Anke Reinacher-SchickWolff Schmiegel
May 9, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E J D Van CutsemUNKNOWN ESMO Guidelines Working Group

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Citations

Dec 16, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Maria R ParkhurstSteven A Rosenberg
Mar 5, 2013·Journal of Cancer Research and Clinical Oncology·D P ModestC J Bruns

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